Limited usefulness of histopathological features in identification of a clinically aggressive solid-pseudopapillary neoplasm of the pancreas

Solid-pseudopapillary neoplasms (SPN) are rare tumours of the pancreas. Distant metastases and/or local recurrence following surgical resection occur in 10% to 15% of patients with SPN. In the present study, we aimed to systematically examine the usefulness of virtually all histopathological feature...

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Bibliographic Details
Published in:Polish journal of pathology 2014-10, Vol.65 (3), p.182-193
Main Authors: Liszka, L, Mrowiec, S, Pająk, J, Kostrząb-Zdebel, A, Lampe, P, Kajor, M
Format: Article
Language:English
Subjects:
Adult
Aged
Antigens
Biopsy
Carcinoma, Papillary - pathology
Female
Gender
Histopathology
Humans
Immunohistochemistry
Male
Medical prognosis
Medical research
Metastasis
Middle Aged
Pancreas
Pancreatic Neoplasms - pathology
Patients
Risk Factors
Software
Stains & staining
Tissue Array Analysis
Tumors
Young Adult
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Description
Summary:Solid-pseudopapillary neoplasms (SPN) are rare tumours of the pancreas. Distant metastases and/or local recurrence following surgical resection occur in 10% to 15% of patients with SPN. In the present study, we aimed to systematically examine the usefulness of virtually all histopathological features of SPN which were previously considered potential risk factors of clinically aggressive behaviour of SPN following surgical resection. Seventeen SPN were included. None of the cases had an undifferentiated component. Follow-up data were available for 14 patients (median 52 months). One patient developed liver metastasis 17 months after resection of the primary tumour and fulfilled the criteria of a clinically aggressive disease. None of the histopathological features allowed identification of that case with an adequate diagnostic yield. At present, histopathological examination cannot identify patients who may develop tumour recurrence following resection of the primary lesion. A close follow-up should be offered to all patients treated for SPN.
ISSN:1233-9687
2084-9869
DOI:10.5114/PJP.2014.45780