HDL and cardiovascular disease

Summary The cholesterol contained within HDL is inversely associated with risk of coronary heart disease and is a key component of predicting cardiovascular risk. However, despite its properties consistent with atheroprotection, the causal relation between HDL and atherosclerosis is uncertain. Human...

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Bibliographic Details
Published in:The Lancet (British edition) 2014-08, Vol.384 (9943), p.618-625
Main Authors: Rader, Daniel J, Prof, Hovingh, G Kees, MD
Format: Article
Language:English
Subjects:
Animals
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - etiology
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - prevention & control
Cholesterol
Cholesterol, HDL - metabolism
Genetics
Health risks
Heart attacks
Humans
Hypercholesterolemia - complications
Hypercholesterolemia - drug therapy
Hypercholesterolemia - metabolism
Hypolipidemic Agents - pharmacology
Internal Medicine
Lipids
Risk Assessment
Risk Factors
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Summary:Summary The cholesterol contained within HDL is inversely associated with risk of coronary heart disease and is a key component of predicting cardiovascular risk. However, despite its properties consistent with atheroprotection, the causal relation between HDL and atherosclerosis is uncertain. Human genetics and failed clinical trials have created scepticism about the HDL hypothesis. Nevertheless, drugs that raise HDL-C concentrations, cholesteryl ester transfer protein inhibitors, are in late-stage clinical development, and other approaches that promote HDL function, including reverse cholesterol transport, are in early-stage clinical development. The final chapters regarding the effect of HDL-targeted therapeutic interventions on coronary heart disease events remain to be written.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(14)61217-4