Nonalcoholic Fatty Liver Disease (NAFLD) And Cardiovascular Risk In Renal Transplant Recipients

Background/Aims: Renal transplant recipients (RTRs) are at high risk for cardiovascular (CVD) mortality. Recently, nonalcoholic fatty liver disease (NAFLD) has been recognized as a new risk factor for adverse CVD events in the general population. We examined whether transient elastography (TE) defin...

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Bibliographic Details
Published in:Kidney & blood pressure research 2014-01, Vol.39 (4), p.308-314
Main Authors: Mikolasevic, Ivana, Racki, Sanjin, Zaputovic, Luka, Lukenda, Vesna, Sladoje-Martinovic, Branka, Orlic, Lidija
Format: Article
Language:English
Subjects:
Aged
Cardiovascular disease
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - etiology
Carotid Intima-Media Thickness
Elasticity Imaging Techniques
Female
Humans
Kidney Transplantation
Liver Cirrhosis - epidemiology
Liver Cirrhosis - pathology
Male
Middle Aged
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - epidemiology
Non-alcoholic Fatty Liver Disease - pathology
Nonalcoholic fatty liver disease (NAFLD)
Original Paper
Plaque, Atherosclerotic - epidemiology
Plaque, Atherosclerotic - pathology
Postoperative Complications - epidemiology
Postoperative Complications - pathology
Renal transplant recipients
Risk Factors
Transient elastography
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Summary:Background/Aims: Renal transplant recipients (RTRs) are at high risk for cardiovascular (CVD) mortality. Recently, nonalcoholic fatty liver disease (NAFLD) has been recognized as a new risk factor for adverse CVD events in the general population. We examined whether transient elastography (TE) defined NAFLD was associated with atherosclerosis in RTRs, as measured by ultrasound in the carotid arteries. Methods: Carotid atherosclerosis was assesses in 71 RTRs with a TE proven NAFLD. With the help of TE liver stiffness was used to assess liver fibrosis and Controlled Attenuation Parameter (CAP) was used to detect and quantify liver steatosis. NAFLD was defined by the presence of steatosis with CAP values ≥238 dB.m -1 . Results: RTRs with NAFLD showed more carotid atherosclerosis than RTRs without NAFLD. RTRs-NAFLD patients had the mean intima-media measurements (ITM) of 1.1±0.1 mm and that was statistically significant higher than the mean ITM founded in RTRs without NAFLD (1.1±0.1 vs. 0.9±0.1 mm; p
ISSN:1420-4096
1423-0143
DOI:10.1159/000355808