Consideration of nutrient levels in studies of cognitive decline

Epidemiological studies suggest that certain micronutrients may improve or maintain cognitive function. Consistent demonstration of benefits in intervention trials has been elusive, possibly because most intervention trials do not select subjects on the basis of nutrient status and/or intake. The ob...

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Bibliographic Details
Published in:Nutrition reviews 2014-11, Vol.72 (11), p.707-719
Main Authors: Barnes, Jennifer L, Tian, Min, Edens, Neile K, Morris, Martha Clare
Format: Article
Language:English
Subjects:
adults
Biological and medical sciences
blood serum
central nervous system diseases
cognition
Cognition Disorders
Cognitive ability
elderly
epidemiological studies
Feeding. Feeding behavior
folate
folic acid
Fundamental and applied biological sciences. Psychology
Humans
malnutrition
Medical sciences
Metabolic diseases
Micronutrients - administration & dosage
Micronutrients - therapeutic use
Neurological disorders
nutrient content
nutrients
Nutrition
nutritional intervention
Nutritional Status
observational studies
Older people
Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin B
vitamin B12
Vitamin E
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Summary:Epidemiological studies suggest that certain micronutrients may improve or maintain cognitive function. Consistent demonstration of benefits in intervention trials has been elusive, possibly because most intervention trials do not select subjects on the basis of nutrient status and/or intake. The objective of this review was to identify levels of intake or markers of nutrient insufficiency that define at‐risk older adult populations to determine whether these populations will benefit from nutritional intervention. This review examines evidence from interventional and prospective observational studies that evaluated the effects of folate, vitamin B₁₂, and vitamin E on cognitive decline in older populations. The studies suggest that supplementation may protect against cognitive decline when serum folate is
ISSN:0029-6643
1753-4887
DOI:10.1111/nure.12144