Hydrogen Sulfide Endothelin-Induced Myocardial Hypertrophy in Rats and the Mechanism Involved

The aim of the study was to evaluate the clinical efficacy of hydrogen sulfide (H 2 S) treatment on the endothelin-induced cardiac hypertrophy. Sixty-four adult male rats, weighing from 180 to 200 g, were randomly divided into four groups: ten in normal group, ten in sham group, 44 in model group es...

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Bibliographic Details
Published in:Cell biochemistry and biophysics 2014-12, Vol.70 (3), p.1683-1686
Main Authors: Yang, Fengyong, Liu, Zhen, Wang, Yajing, Li, Zhaoxin, Yu, Haichu, Wang, Qixin
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biotechnology
Cardiomegaly - chemically induced
Cardiomegaly - drug therapy
Cardiomegaly - metabolism
Cell Biology
Collagen - metabolism
Disease Models, Animal
Endothelins - toxicity
Heart Ventricles - drug effects
Heart Ventricles - metabolism
Hydrogen sulfide
Hydrogen Sulfide - pharmacology
Hydrogen Sulfide - therapeutic use
Life Sciences
Male
Myocardium - metabolism
Myocytes, Cardiac - drug effects
Myocytes, Cardiac - metabolism
Organ Size - drug effects
Original Paper
Pharmacology/Toxicology
Rats
Rats, Sprague-Dawley
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Summary:The aim of the study was to evaluate the clinical efficacy of hydrogen sulfide (H 2 S) treatment on the endothelin-induced cardiac hypertrophy. Sixty-four adult male rats, weighing from 180 to 200 g, were randomly divided into four groups: ten in normal group, ten in sham group, 44 in model group established by inducing the myocardial hypertrophy with endothelin. The myocardial hypertrophy model rats were randomly divided into two groups: 22 in the simple myocardial hypertrophy model group and 22 in the H 2 S treatment group. Rats in normal group were given 2 ml pure water by gavage per day, those in the sham group and simple cardiac hypertrophy model group were given 2 ml of saline by gavage per day, and rats in the pure cardiac hypertrophy with H 2 S treatment were given intraperitoneal injections of 2 ml NaHS saline per day for a period of 4 weeks. Left ventricular mass index, myocyte hypertrophy, volume fraction of myocardial interstitial collagen, myocardial hydroxyproline content and other indicators of cardiac hypertrophy were observed after 4 weeks. (1) There were significant differences on the ventricular mass between the treatment group and the cardiac hypertrophy group: The left ventricular mass decreased 21.4 % and the left ventricular mass index decreased 5.97 % ( P  
ISSN:1085-9195
1559-0283
DOI:10.1007/s12013-014-0113-3