E‐cadherin expression in upper‐urinary‐tract carcinoma

• Published in: International journal of cancer 1997-08, Vol.74 (4), p.446-449
• Main Authors: Nakanishi, Kuniaki, Kawai, Toshiaki, Torikata, Chikao, Aurues, Takashi, Ikeda, Tomosumi
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Analysis of Variance; Biological and medical sciences; Cadherins - analysis; Cadherins - biosynthesis; Carcinoma, Transitional Cell - mortality; Carcinoma, Transitional Cell - pathology; Carcinoma, Transitional Cell - surgery; Cell Division; Chi-Square Distribution; Disease-Free Survival; Female; Humans; Immunohistochemistry; Kidney Neoplasms - mortality; Kidney Neoplasms - pathology; Kidney Neoplasms - surgery; Male; Medical sciences; Middle Aged; Neoplasm Staging; Nephrology. Urinary tract diseases; Predictive Value of Tests; Survival Rate; Tumors of the urinary system; Ureteral Neoplasms - mortality; Ureteral Neoplasms - pathology; Ureteral Neoplasms - surgery; Urinary Bladder Neoplasms - mortality; Urinary Bladder Neoplasms - pathology; Urinary Bladder Neoplasms - surgery; Urinary tract. Prostate gland
• ISSN: 0020-7136; 1097-0215
• DOI: 10.1002/(SICI)1097-0215(19970822)74:4<446::AID-IJC15>3.0.CO;2-7

Carcinoma of the upper urinary tract is a relatively rare neoplasm, and few studies have dealt with clinicopathological findings and prognosis in a large number of cases. The purpose of our investigation was to look for a possible relation between E‐cadherin (E‐CD) immunoreactivity and clinicopathologic findings or clinical outcome in transitional‐cell carcinoma of the upper urinary tract (TCC‐UUT). To this end, we investigated E‐CD immunoreactivity in 154 cases of TCC‐UUT. E‐CD immunoreactivity was recognized as being of “normal” pattern in 29.2% of samples. The relationship between E‐CD immunoreactivity and clinicopathologic findings was significant for stage, grade and pattern of growth. The 5‐year disease‐free rate for 147 cases and 5‐year overall survival rate for 154 cases were 55.7% and 71.5%, respectively. A univariate analysis of survival revealed that stage, grade, pattern of growth and E‐CD immunoreactivity all had a significant effect on disease‐free and overall survival rates. In the final models of multivariate analysis, however, we found that, for disease‐free survival and for overall survival, only stage was a factor for progression or prognosis. Detection of E‐CD immunoreactivity appears to be of limited value in deciding the prognosis of TCC‐UUT. Int. J. Cancer 74:446–449, 1997. © 1997 Wiley‐Liss, Inc.