Effect of prazosin on sperm transport in male rats

• Published in: Reproductive toxicology (Elmsford, N.Y.) N.Y.), 1997-07, Vol.11 (4), p.627-631
• Main Authors: Solomon, Howard M, Wier, Patrick J, Ippolito, Danielle L, Toscano, Thomas V
• Format: Article
• Language: English
• Subjects: Adrenergic alpha-Antagonists - toxicity; Animals; Biological and medical sciences; Drug toxicity and drugs side effects treatment; Ejaculation - drug effects; ex vivo; Female; Male; Medical sciences; Pharmacology. Drug treatments; prazosin; Prazosin - toxicity; rat; Rats; Rats, Sprague-Dawley; Sperm Count; Sperm Motility - drug effects; sperm transport; Toxicity: urogenital system
• ISSN: 0890-6238; 1873-1708
• DOI: 10.1016/S0890-6238(97)00022-1

Our objective was to investigate ejaculation and transport of sperm in the reproductive tract of male rats treated with an alpha-adrenergic receptor antagonist. Males were dosed (SC) with vehicle or 1.4 mg/kg prazosin. Sperm recovered in utero and ex vivo from the vas deferens and cauda epididymis were evaluated. Mating behavior and sperm motility were unaffected by prazosin. Prazosin treated males ejaculated fewer sperm (12.58 ± 8.12 vs. 110.5 ± 29.15 million), and the distal vas deferens contained fewer sperm (2.72 ± 0.84 vs. 24.42 ± 3.25 million) relative to controls. Prazosin-treated males had more sperm in the cauda epididymis relative to controls indicating inhibition of sperm transport to the vas deferens. These data demonstrate that inhibition of sperm transport from the cauda epididymis to the distal vas deferens is related to low ejaculate sperm counts in prazosin treated rats.