Effect of prazosin on sperm transport in male rats

Our objective was to investigate ejaculation and transport of sperm in the reproductive tract of male rats treated with an alpha-adrenergic receptor antagonist. Males were dosed (SC) with vehicle or 1.4 mg/kg prazosin. Sperm recovered in utero and ex vivo from the vas deferens and cauda epididymis w...

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Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 1997-07, Vol.11 (4), p.627-631
Main Authors: Solomon, Howard M, Wier, Patrick J, Ippolito, Danielle L, Toscano, Thomas V
Format: Article
Language:English
Subjects:
Adrenergic alpha-Antagonists - toxicity
Animals
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Ejaculation - drug effects
ex vivo
Female
Male
Medical sciences
Pharmacology. Drug treatments
prazosin
Prazosin - toxicity
rat
Rats
Rats, Sprague-Dawley
Sperm Count
Sperm Motility - drug effects
sperm transport
Toxicity: urogenital system
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cited_by cdi_FETCH-LOGICAL-c515t-32b6c0d17ddc27a3b8b052727b1cc003b9447afbecfc57ab103f31b45d2e0e073
cites cdi_FETCH-LOGICAL-c515t-32b6c0d17ddc27a3b8b052727b1cc003b9447afbecfc57ab103f31b45d2e0e073
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container_issue 4
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container_title Reproductive toxicology (Elmsford, N.Y.)
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creator Solomon, Howard M
Wier, Patrick J
Ippolito, Danielle L
Toscano, Thomas V
description Our objective was to investigate ejaculation and transport of sperm in the reproductive tract of male rats treated with an alpha-adrenergic receptor antagonist. Males were dosed (SC) with vehicle or 1.4 mg/kg prazosin. Sperm recovered in utero and ex vivo from the vas deferens and cauda epididymis were evaluated. Mating behavior and sperm motility were unaffected by prazosin. Prazosin treated males ejaculated fewer sperm (12.58 ± 8.12 vs. 110.5 ± 29.15 million), and the distal vas deferens contained fewer sperm (2.72 ± 0.84 vs. 24.42 ± 3.25 million) relative to controls. Prazosin-treated males had more sperm in the cauda epididymis relative to controls indicating inhibition of sperm transport to the vas deferens. These data demonstrate that inhibition of sperm transport from the cauda epididymis to the distal vas deferens is related to low ejaculate sperm counts in prazosin treated rats.
doi_str_mv 10.1016/S0890-6238(97)00022-1
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subjects Adrenergic alpha-Antagonists - toxicity
Animals
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Ejaculation - drug effects
ex vivo
Female
Male
Medical sciences
Pharmacology. Drug treatments
prazosin
Prazosin - toxicity
rat
Rats
Rats, Sprague-Dawley
Sperm Count
Sperm Motility - drug effects
sperm transport
Toxicity: urogenital system
title Effect of prazosin on sperm transport in male rats
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