pp125 super(FAK), a structurally distinctive protein-tyrosine kinase associated with focal adhesions

We report here the isolation of a cDNA encoding a protein, pp125, that is a major phosphotyrosine-containing protein in untransformed chicken embryo cells and exhibits an increase in phosphotyrosine in pp60 super(v-src)-transformed chicken embryo cells. This cDNA encodes a cytoplasmic protein-tyrosi...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1992-01, Vol.89 (11), p.5192-5196
Main Authors: Schaller, MD, Borgman, CA, Cobb, B S, Vines, R R, Reynolds, AB, Parsons, J T
Format: Article
Language:English
Subjects:
amino acid sequence
cDNA
cells
chickens
focal adhesion kinase
genes
nucleotide sequence
predictions
protein-tyrosine kinase
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report here the isolation of a cDNA encoding a protein, pp125, that is a major phosphotyrosine-containing protein in untransformed chicken embryo cells and exhibits an increase in phosphotyrosine in pp60 super(v-src)-transformed chicken embryo cells. This cDNA encodes a cytoplasmic protein-tyrosine kinase which, based upon its predicted amino acid sequence and structure, is the prototype for an additional family of protein-tyrosine kinases. Immunofluorescence localization experiments show that pp125 is localized to focal adhesions; hence, we suggest the name focal adhesion kinase.
ISSN:0027-8424