Characterization of ethylguanine isomers and structurally related compounds by laser-desorbed cationization in a Fourier transform mass spectrometer

Laser-desorption Fourier transform mass spectrometry (LD-FTMS) was used to investigate and compare the fragmentation patterns of O 6-, 7- and 9-ethylguanines. LD-FTMS of all ethylguanine isomers studied here gave characteristic fragmentations in addition to pseudomolecular ions. These ethylguanine i...

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Bibliographic Details
Published in:Analytica chimica acta 1991-07, Vol.247 (2), p.235-241
Main Authors: Giam, C.S., Ahmed, M.S., McAdoo, D.J., Zheng, Y., Holliday, T.L.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chemical mutagenesis
Collision-induced dissociation
Ethylguanine isomers
Laser desorption
Mass spectrometry
Medical sciences
Toxicology
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Summary:Laser-desorption Fourier transform mass spectrometry (LD-FTMS) was used to investigate and compare the fragmentation patterns of O 6-, 7- and 9-ethylguanines. LD-FTMS of all ethylguanine isomers studied here gave characteristic fragmentations in addition to pseudomolecular ions. These ethylguanine isomers lose ethylene leading to the formation of protonated guanine. O 6-Ethylguanine readily loses acetaldehyde from molecular and pseudomolecular ions, however, acetaldehyde elimination was not observed in the spectra of 7- and 9-ethylguanines. Ionized O 6- and 7-ethylguanines both lose methyl radicals whereas ionized 9-ethylguanine does not. Fragmentation pathways for formation of some of the distinguishing ions are proposed. Collision-induced dissociation was also carried out to identify some of the fragment ions.
ISSN:0003-2670
1873-4324
DOI:10.1016/S0003-2670(00)83818-0