Targeting breast cancer initiating cells: Advances in breast cancer research and therapy

Over the past 10 years there have been significant advances in our understanding of breast cancer and the important roles that breast cancer initiating cells (CICs) play in the development and resistance of breast cancer. Breast CICs endowed with self-renewing and tumor-initiating capacities are bel...

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Bibliographic Details
Published in:Advances in biological regulation 2014-09, Vol.56, p.81-107
Main Authors: McCubrey, James A., Davis, Nicole M., Abrams, Stephen L., Montalto, Giuseppe, Cervello, Melchiorre, Libra, Massimo, Nicoletti, Ferdinando, D'Assoro, Antonino B., Cocco, Lucio, Martelli, Alberto M., Steelman, Linda S.
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Breast Neoplasms - drug therapy
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Cancer stem cells
Female
HER2
Hormonal therapy
Humans
miRs
Neoplastic Stem Cells - drug effects
Neoplastic Stem Cells - metabolism
Proteins - genetics
Proteins - metabolism
Targeted therapy
Therapy resistance
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Summary:Over the past 10 years there have been significant advances in our understanding of breast cancer and the important roles that breast cancer initiating cells (CICs) play in the development and resistance of breast cancer. Breast CICs endowed with self-renewing and tumor-initiating capacities are believed to be responsible for the relapses which often occur after various breast cancer therapies. In this review, we will summarize some of the key developments in breast CICs which will include discussion of some of the key genes implicated: estrogen receptor (ER), HER2, BRCA1, TP53, PIK3CA, RB, P16INK1 and various miRs as well some drugs which are showing promise in targeting CICs. In addition, the concept of combined therapies will be discussed. Basic and clinical research is resulting in novel approaches to improve breast cancer therapy by targeting the breast CICs.
ISSN:2212-4926
2212-4934
DOI:10.1016/j.jbior.2014.05.003