Chronic posttraumatic cartilage lesion of the knee treated with an acellular osteochondral-regenerating implant: case history with rehabilitation guidelines

Osteochondral defects are often symptomatic and lead to deranged joint function. The spontaneous healing capacity of osteochondral defects is limited. In this case study, use of an acellular scaffold capable of induction of mesenchymal stem-cell migration is described. This scaffold was used on an O...

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Bibliographic Details
Published in:Journal of sport rehabilitation 2014-08, Vol.23 (3), p.270-275
Main Authors: Kon, Elizaveta, Drobnic, Matej, Davidson, Phil A, Levy, Andrew, Zaslav, Ken R, Robinson, Dror
Format: Article
Language:English
Subjects:
Cartilage
Cartilage, Articular - diagnostic imaging
Cartilage, Articular - injuries
Cartilage, Articular - surgery
Cell adhesion & migration
Chronic Pain
Humans
Knee
Knee Injuries - rehabilitation
Male
Mesenchymal Stromal Cells - metabolism
Middle Aged
Radiography
Tissue Scaffolds
Transplants & implants
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Description
Summary:Osteochondral defects are often symptomatic and lead to deranged joint function. The spontaneous healing capacity of osteochondral defects is limited. In this case study, use of an acellular scaffold capable of induction of mesenchymal stem-cell migration is described. This scaffold was used on an Outerbridge grade IV medical condylar defect measuring ~2 cm2. At 24 mo follow-up, the articular surface appeared restored by MRI, and the patient returned to sports.
ISSN:1056-6716
1543-3072
DOI:10.1123/jsr.2013-0054