Enhanced invasion of lung adenocarcinoma cells after co-culture with THP-1-derived macrophages via the induction of EMT by IL-6

Highlights • The concentrations of IL-6 in co-culture supernatants increased. • The lung cancer cells educated by macrophages were the main source of IL-6 secretion. • IL-6 promoted the invasion of lung cancer cells by EMT. • Macrophages differentiated to M2 phenotype during the process of co-cultur...

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Bibliographic Details
Published in:Immunology letters 2014-07, Vol.160 (1), p.1-10
Main Authors: Dehai, Che, Bo, Pan, Qiang, Tian, Lihua, Shang, Fang, Liu, Shi, Jin, Jingyan, Cao, Yan, Yu, Guangbin, Wang, Zhenjun, Yuan
Format: Article
Language:English
Subjects:
A549 and H1299 cells
Adenocarcinoma - immunology
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Adenocarcinoma of Lung
Allergy and Immunology
Biomarkers - metabolism
Cell Line, Tumor
Co-culture
Coculture Techniques
EMT
Epithelial-Mesenchymal Transition - drug effects
Humans
IL-6
Interleukin-6 - biosynthesis
Interleukin-6 - pharmacology
Invasion
Lung Neoplasms - immunology
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Macrophages - immunology
Macrophages - metabolism
Macrophages - pathology
Neoplasm Invasiveness
Phenotype
THP-1-derived macrophages
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Summary:Highlights • The concentrations of IL-6 in co-culture supernatants increased. • The lung cancer cells educated by macrophages were the main source of IL-6 secretion. • IL-6 promoted the invasion of lung cancer cells by EMT. • Macrophages differentiated to M2 phenotype during the process of co-culture. • Inhibition of IL-6 may be an effective anti-cancer therapy.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2014.03.004