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Enhanced invasion of lung adenocarcinoma cells after co-culture with THP-1-derived macrophages via the induction of EMT by IL-6

Highlights • The concentrations of IL-6 in co-culture supernatants increased. • The lung cancer cells educated by macrophages were the main source of IL-6 secretion. • IL-6 promoted the invasion of lung cancer cells by EMT. • Macrophages differentiated to M2 phenotype during the process of co-cultur...

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Published in:	Immunology letters 2014-07, Vol.160 (1), p.1-10
Main Authors:	Dehai, Che, Bo, Pan, Qiang, Tian, Lihua, Shang, Fang, Liu, Shi, Jin, Jingyan, Cao, Yan, Yu, Guangbin, Wang, Zhenjun, Yuan
Format:	Article
Language:	English
Subjects:	A549 and H1299 cells Adenocarcinoma - immunology Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma of Lung Allergy and Immunology Biomarkers - metabolism Cell Line, Tumor Co-culture Coculture Techniques EMT Epithelial-Mesenchymal Transition - drug effects Humans IL-6 Interleukin-6 - biosynthesis Interleukin-6 - pharmacology Invasion Lung Neoplasms - immunology Lung Neoplasms - metabolism Lung Neoplasms - pathology Macrophages - immunology Macrophages - metabolism Macrophages - pathology Neoplasm Invasiveness Phenotype THP-1-derived macrophages
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container_title	Immunology letters
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description	Highlights • The concentrations of IL-6 in co-culture supernatants increased. • The lung cancer cells educated by macrophages were the main source of IL-6 secretion. • IL-6 promoted the invasion of lung cancer cells by EMT. • Macrophages differentiated to M2 phenotype during the process of co-culture. • Inhibition of IL-6 may be an effective anti-cancer therapy.
doi_str_mv	10.1016/j.imlet.2014.03.004
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subjects	A549 and H1299 cells Adenocarcinoma - immunology Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma of Lung Allergy and Immunology Biomarkers - metabolism Cell Line, Tumor Co-culture Coculture Techniques EMT Epithelial-Mesenchymal Transition - drug effects Humans IL-6 Interleukin-6 - biosynthesis Interleukin-6 - pharmacology Invasion Lung Neoplasms - immunology Lung Neoplasms - metabolism Lung Neoplasms - pathology Macrophages - immunology Macrophages - metabolism Macrophages - pathology Neoplasm Invasiveness Phenotype THP-1-derived macrophages
title	Enhanced invasion of lung adenocarcinoma cells after co-culture with THP-1-derived macrophages via the induction of EMT by IL-6
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