Hexabromocyclododecane concentrations in Canadian human fetal liver and placental tissues

Detectable concentrations of the flame retardant hexabromocyclododecane (HBCD) have been reported in human tissues worldwide, but investigations to determine fetal exposure to this brominated flame retardant are lacking. This study was undertaken to determine the concentrations of α-, β- and γ-HBCD...

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Bibliographic Details
Published in:The Science of the total environment 2014-01, Vol.468-469, p.622-629
Main Authors: Rawn, Dorothea F.K., Gaertner, Dean W., Weber, Dorcas, Curran, Ivan H.A., Cooke, Gerard M., Goodyer, Cynthia G.
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Brominated flame retardants
Chromatography, Liquid
Environmental Monitoring - methods
Environmental Monitoring - statistics & numerical data
Female
Fetus - metabolism
Flame Retardants - metabolism
Flame Retardants - pharmacokinetics
HBCD
Hexabromocyclododecane
Human tissues
Humans
Hydrocarbons, Brominated - metabolism
Hydrocarbons, Brominated - pharmacokinetics
Liver - metabolism
PBDEs
Placenta - metabolism
Pregnancy
Quebec
Tandem Mass Spectrometry
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Summary:Detectable concentrations of the flame retardant hexabromocyclododecane (HBCD) have been reported in human tissues worldwide, but investigations to determine fetal exposure to this brominated flame retardant are lacking. This study was undertaken to determine the concentrations of α-, β- and γ-HBCD in human tissues (fetal liver and placenta) from Canada. Tissue samples were collected over a thirteen year period following elective pregnancy terminations in Montreal, Quebec, Canada. Samples were extracted using homogenisation with solvent, cleaned up using adsorption chromatography and analysis was performed with liquid chromatography-tandem mass spectrometry. Total HBCD concentrations ranged from below the limit of detection (
ISSN:0048-9697
1879-1026
DOI:10.1016/j.scitotenv.2013.08.014