Distribution of ABCB1, CYP3A5, CYP2C19, and P2RY12 gene polymorphisms in a Mexican Mestizos population

The aim of the present study was to establish the gene frequency of six polymorphisms of the ABCB1, CYP3A5, CYP2C19, and P2RY12 genes in a population resident of Mexico City. The proteins encoded by these genes have been associated with the absorption, and biotransformation of clopidogrel. The ABCB1...

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Bibliographic Details
Published in:Molecular biology reports 2014-10, Vol.41 (10), p.7023-7029
Main Authors: Vargas-Alarcón, Gilberto, Ramírez-Bello, Julián, de la Peña, Aurora, Calderón-Cruz, Beatriz, Peña-Duque, Marco Antonio, Martínez-Ríos, Marco Antonio, Ramírez-Fuentes, Silvestre, Pérez-Méndez, Oscar, Fragoso, José Manuel
Format: Article
Language:English
Subjects:
Alleles
Animal Anatomy
Animal Biochemistry
ATP Binding Cassette Transporter, Sub-Family B - genetics
Biomedical and Life Sciences
Cytochrome P-450 CYP2C19 - genetics
Cytochrome P-450 CYP3A - genetics
Ethnic Groups - genetics
Female
Gene Frequency
Genes
Genotype
Histology
Humans
Life Sciences
Linkage Disequilibrium
Male
Mexico
Morphology
Polymorphism
Polymorphism, Genetic
Population genetics
Receptors, Purinergic P2Y12 - genetics
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Summary:The aim of the present study was to establish the gene frequency of six polymorphisms of the ABCB1, CYP3A5, CYP2C19, and P2RY12 genes in a population resident of Mexico City. The proteins encoded by these genes have been associated with the absorption, and biotransformation of clopidogrel. The ABCB1 T3435C, CYP3A5 V3* A6986G, P2RY12 G52T , P2RY12 C34T, CYP2C19 V2* and V3* (positions G681A and G636A, respectively ), polymorphisms were analyzed by 5′ exonuclease TaqMan genotyping assays in a group of 269 healthy unrelated Mexican Mestizo individuals. The CYP2C19 V3* G636A polymorphism was not detected in the Mexican Mestizos population. However, the studied population presented significant differences ( P  
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-014-3590-y