C/EBP α and C/EBP β play similar roles in the transcription of the human Cu/Zn SOD gene

Copper/zinc-containing superoxide dismutase (Cu/Zn SOD) is one of the essential enzymes that protects cells in aerobic conditions. To understand the mechanism of transcriptional regulation of the human Cu/Zn SOD gene, the proximal promoter region of Cu/Zn SOD has been investigated. In a previous stu...

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Bibliographic Details
Published in:Gene 1997-12, Vol.203 (1), p.11-15
Main Authors: Seo, Seong Jin, Kang, Sang Sun, Cho, Ginam, Rho, Hyune Mo, Jung, Guhung
Format: Article
Language:English
Subjects:
C/EBP
Promoter
Sp1
Superoxide dismutase
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Summary:Copper/zinc-containing superoxide dismutase (Cu/Zn SOD) is one of the essential enzymes that protects cells in aerobic conditions. To understand the mechanism of transcriptional regulation of the human Cu/Zn SOD gene, the proximal promoter region of Cu/Zn SOD has been investigated. In a previous study, it was found that transcription factors of the Sp1 and C/EBP family are associated with the expression of human Cu/Zn SOD [Seo et al. (1996). Gene, 178, 177-180]. Of the four known C/EBP activators, the effects of C/EBP α and C/EBP β on the transcription of Cu/Zn SOD were examined. Usually, one of the two C/EBP factors, C/EBP α or C/EBP β, exclusively stimulates the target gene, but, unexpectedly, C/EBP α and C/EBP β stimulated the expression of Cu/Zn SOD to a similar extent in our experiments. LIP, a dominant negative regulator of the C/EBP family, inhibited the transcriptional activation of Cu/Zn SOD stimulated by C/EBP α and C/EBP β. These results suggest that C/EBP α and C/EBP β can substitute each other and play similar roles on the transcription of Cu/Zn SOD.
ISSN:0378-1119
1879-0038
DOI:10.1016/S0378-1119(97)00484-8