Delayed Generation of Antibodies Mediating Human Immunodeficiency Virus Type 1-Specific Antibody-Dependent Cellular Cytotoxicity in Vertically Infected Infants

Human immunodeficiency virus type 1 (HIV-1)-specific antibody-dependent cellular cytotoxicity (ADCC) antibody titers were serially measured from birth to 24 months in the plasma of 14 intrapartum-infected and 10 uninfected infants born to HIV-1-infected women. The mean ADCC antibody titers measured...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 1997-09, Vol.176 (3), p.643-648
Main Authors: Pugatch, David, Sullivan, John L., Pikora, Cheryl A., Luzuriaga, Katherine
Format: Article
Language:English
Subjects:
Antibodies
Antibody dependent cell cytotoxicity
Biological and medical sciences
Cytotoxicity
Disease progression
HIV
HIV 1
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infants
Infections
Major Articles
Medical sciences
T lymphocytes
Viruses
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Human immunodeficiency virus type 1 (HIV-1)-specific antibody-dependent cellular cytotoxicity (ADCC) antibody titers were serially measured from birth to 24 months in the plasma of 14 intrapartum-infected and 10 uninfected infants born to HIV-1-infected women. The mean ADCC antibody titers measured at birth in infected and uninfected infants were similar (10−3.9 and 10−4.0, respectively), suggesting that ADCC antibodies did not protect infants from the intrapartum transmission of HIV-1. In infected infants, ADCC titers at birth did not predict subsequent clinical disease course. The active production of HIV-1-specific ADCC antibodies was detected in most infected infants only after 12 months of age, well after the loss of passively acquired maternal ADCC antibody. The delayed production of ADCC antibodies in infancy may account, in part, for the less efficient control of viral replication and more rapid disease progression following vertical infection compared with that in adults.
ISSN:0022-1899
1537-6613
DOI:10.1086/514085