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p70 S6 kinase: an enigma with variations

The S6 ribosomal protein is phosphorylated by p70 S6 kinase (p70 S6k). Although the cellular role of S6 phosphorylation is still not fully clear, studies on p70 S6k and its activation have revealed the existence of a novel signalling pathway, clues to the mechanism of action of certain immunosuppres...

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Published in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 1996-05, Vol.21 (5), p.181-185
Main Author:	Proud, Christopher G.
Format:	Article
Language:	English
Subjects:	Enzyme Activation Gene Expression Regulation Immunosuppressive Agents - pharmacology Models, Biological Mutagenesis Phosphatidylinositol 3-Kinases Phosphotransferases (Alcohol Group Acceptor) - metabolism Polyenes - pharmacology Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Ribosomal Protein S6 Kinases Signal Transduction Sirolimus
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description	The S6 ribosomal protein is phosphorylated by p70 S6 kinase (p70 S6k). Although the cellular role of S6 phosphorylation is still not fully clear, studies on p70 S6k and its activation have revealed the existence of a novel signalling pathway, clues to the mechanism of action of certain immunosuppressants and insights into the control of gene expression at the levels of transcription and translation.
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subjects	Enzyme Activation Gene Expression Regulation Immunosuppressive Agents - pharmacology Models, Biological Mutagenesis Phosphatidylinositol 3-Kinases Phosphotransferases (Alcohol Group Acceptor) - metabolism Polyenes - pharmacology Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Ribosomal Protein S6 Kinases Signal Transduction Sirolimus
title	p70 S6 kinase: an enigma with variations
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