Biochemical identification of an extracellular glycoprotein (ECM56) in human brain tumors

In malignant Morris hepatoma 7777 of the rat, an extracellular glycoprotein with high molecular weight was identified. In the present study of human brain tumors, we have detected an identical extracellular glycoprotein with a molecular weight of 56 kDa (ECM56) under reducing conditions, which belon...

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Bibliographic Details
Published in:Neuroscience research communications 1997-01, Vol.20 (1), p.41-47
Main Authors: Lee, Jin-Yul, Ernestus, Ralf-Ingo, Riese, Hans-Heinz, Cervós-Navarro, Jorge, Reutter, Werner
Format: Article
Language:English
Subjects:
brain tumor
extracellular glycoprotein
extracellular matrix
Morris hepatoma
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Summary:In malignant Morris hepatoma 7777 of the rat, an extracellular glycoprotein with high molecular weight was identified. In the present study of human brain tumors, we have detected an identical extracellular glycoprotein with a molecular weight of 56 kDa (ECM56) under reducing conditions, which belongs to the group of high molecular weight glycoproteins. © 1997 John Wiley & Sons, Ltd. Fifteen intraoperatively acquired tissue samples of ten glioblastomas, three astrocytomas WHO grade III, one oligoastrocytoma grade II‐III, one ependymoma grade III, and two normal adult brain specimens obtained at autopsy were investigated. In this series, ECM56 could be detected biochemically in all glioblastomas and ependymomas, but not in astrocytomas and normal adult brain. Immunohisto‐chemically, ECM56 was mainly distributed in tissue areas with vascular proliferation. Thus, ECM56 might be related to malignant neoplastic growth in the brain and, therefore, may represent a biochemical marker of malignancy.
ISSN:0893-6609
1520-6769
DOI:10.1002/(SICI)1520-6769(199701)20:1<41::AID-NRC184>3.0.CO;2-2