Kinetics of nigral degeneration in a chronic model of MPTP-treated mice

The chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model we have developed in monkey reproduces all the cardinal features of Parkinson's disease, and, in particular the characteristic slow evolution of clinical signs. We still know little, however, of the kinetics of the nigral deg...

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Bibliographic Details
Published in:Neuroscience letters 1997-09, Vol.234 (1), p.47-50
Main Authors: Bezard, Erwan, Dovero, Sandra, Bioulac, Bernard, Gross, Christian E
Format: Article
Language:English
Subjects:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Analysis of Variance
Animals
Biological and medical sciences
Cell Death
Chronic Disease
Chronic model
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disease Models, Animal
Kinetics
Male
Medical sciences
Mice
Nerve Degeneration
Neurology
Neurotoxins
Parkinson's disease
Slow evolution of disease
Substantia Nigra - enzymology
Substantia Nigra - physiology
Tyrosine 3-Monooxygenase - analysis
Tyrosine hydroxylase
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Summary:The chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model we have developed in monkey reproduces all the cardinal features of Parkinson's disease, and, in particular the characteristic slow evolution of clinical signs. We still know little, however, of the kinetics of the nigral degeneration induced. This present study charts the progressive destruction of tyrosine hydroxylase-immunoreactive neurones in mice treated daily with low doses of MPTP for 20 days. Our results show that the neuronal death rate is initially high, subsequently decreases, and stabilizes. This new protocol thus mirrors closely the pattern of evolution assumed to be that of Parkinson's disease and should prove useful for studies on neuroprotection and compensatory mechanisms.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(97)00663-0