In vitro activity of 15-azasterol (A25822B) against chalkbrood pathogen Ascosphaera apis in the honey bee

The antifungal agent 15-azasterol A25822B was examined for effects on the growth and development of Ascosphaera apis . The minimum inhibition concentration (MIC) of azasterol against A. apis was 1 mu m. Growth and development of A. apis was completely controlled at this concentration. At a concentra...

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Bibliographic Details
Published in:Mycopathologia (1975) 1991-09, Vol.115 (3), p.175-184
Main Authors: Liu, T.P. (California Univ., Davis, CA (USA). Dept. of Entomology), Peng, C.Y.S, Mussen, E.C, Marston, J.M, Munn, R.J
Format: Article
Language:English
Subjects:
AGENT PATHOGENE
APIS MELLIFERA
ASCOSPHAERA
Ascosphaera apis
Bacteriology
Biological and medical sciences
CONTROL DE ENFERMEDADES
CONTROLE DE MALADIES
DISEASE CONTROL
Fundamental and applied biological sciences. Psychology
METHODE
METHODS
METODOS
Microbiology
Motility, taxis
ORGANISMOS PATOGENOS
PATHOGENS
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Summary:The antifungal agent 15-azasterol A25822B was examined for effects on the growth and development of Ascosphaera apis . The minimum inhibition concentration (MIC) of azasterol against A. apis was 1 mu m. Growth and development of A. apis was completely controlled at this concentration. At a concentration of 0.01 mu m growth of A. apis was retarded and although sporocysts were formed developing spores were not able to reach maturation. A major effect of azasterol at this low concentration was the accumulation of lipid in the hyphae, sporocysts and immature spores. In addition it caused a conformational change in mitochondria and damage to the spore membrane structure. On the basis of these results, further investigations of azasterol for the treatment of chalkbrood disease in the honey bee are warranted.
ISSN:0301-486X
1573-0832
DOI:10.1007/BF00462222