Silicosis, mixed dust pneumoconiosis, and lung cancer

A total of 764 autopsy cases with a pathological diagnosis of nonasbestos pneumoconiosis were investigated in a search for lung cancer: 146 patients bore 148 lung cancers (19.1%). The incidence of a lung cancer was associated positively with aging, longer occupational exposures, and smoking habits....

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Bibliographic Details
Published in:American journal of industrial medicine 1997-12, Vol.32 (6), p.595-599
Main Authors: Honma, Koichi, Chiyotani, Keizo, Kimura, Kiyonobu
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Carcinoma, Small Cell
Carcinoma, Squamous Cell - etiology
Chemical and industrial products toxicology. Toxic occupational diseases
Female
Humans
Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)
lung cancer
Lung Neoplasms - etiology
Male
Medical sciences
Middle Aged
mixed dust pneumoconiosis
occupational lung disease
Pneumoconiosis - complications
Pneumology
Pulmonary Fibrosis - complications
silica
silicosis
Silicosis - complications
smoking
Smoking - adverse effects
Toxicology
Tumors of the respiratory system and mediastinum
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Summary:A total of 764 autopsy cases with a pathological diagnosis of nonasbestos pneumoconiosis were investigated in a search for lung cancer: 146 patients bore 148 lung cancers (19.1%). The incidence of a lung cancer was associated positively with aging, longer occupational exposures, and smoking habits. A reverse correlation was found between carcinogenesis and the severity of pneumoconiosis. A statistically significant increase in the incidence of certain types of lung cancer (squamous cell carcinoma + small cell carcinoma) was found in silicotic lungs with massive fibrosis as compared to lungs with mixed dust pneumoconiosis of comparable severity. Although there appears to be no dose‐response relationship in general between silicosis and lung cancer, it is advisable to consider the possibility that a presumptive silica‐induced carcinogenesis might be masked by the severe fibrosis of a silicotic type, which obliterates the lung tissue in a different way from asbestosis, which is associated with epithelial proliferation. Am. J. Ind. Med. 32:595–599, 1997. © 1997 Wiley‐Liss, Inc.
ISSN:0271-3586
1097-0274
DOI:10.1002/(SICI)1097-0274(199712)32:6<595::AID-AJIM4>3.0.CO;2-P