Restoration of Viral Immunity in Immunodeficient Humans by the Adoptive Transfer of T Cell Clones

The adoptive transfer of antigen-specific T cells to establish immunity is an effective therapy for viral infections and tumors in animal models. The application of this approach to human disease would require the isolation and in vitro expansion of human antigen-specific T cells and evidence that s...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1992-07, Vol.257 (5067), p.238-241
Main Authors: Riddell, Stanley R., Watanabe, Kathe S., Goodrich, James M., Li, Cheng R., Agha, Mounzer E., Greenberg, Philip D.
Format: Article
Language:English
Subjects:
Adoptive transfer
AIDS
Analysis of the immune response. Humoral and cellular immunity
Antigens
Antigens, Differentiation, T-Lymphocyte - immunology
Biological and medical sciences
Bone marrow
Bone Marrow Transplantation - immunology
CD3 Complex
CD4-Positive T-Lymphocytes - immunology
CD8 Antigens - immunology
Cell and tissue based therapy
Cells, Cultured
Cellular therapy
Cultured cells
Cytomegalovirus
Cytomegalovirus infections
Cytomegalovirus Infections - prevention & control
Fibroblasts
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunity
Immunobiology
Immunotherapy
Infections
Killer cells
Organs and cells involved in the immune response
Prevention
Receptors, Antigen, T-Cell - immunology
T lymphocytes
T-Lymphocytes, Cytotoxic - immunology
Vaccination - methods
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Summary:The adoptive transfer of antigen-specific T cells to establish immunity is an effective therapy for viral infections and tumors in animal models. The application of this approach to human disease would require the isolation and in vitro expansion of human antigen-specific T cells and evidence that such T cells persist and function in vivo after transfer. Cytomegalovirus-specific CD8$^+$ cytotoxic T cell (CTL) clones could be isolated from bone marrow donors, propagated in vitro, and adoptively transferred to immunodeficient bone marrow transplant recipients. No toxicity developed and the clones provided persistent reconstitution of CD8$^+$ cytomegalovirus-specific CTL responses.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1352912