Selective Palladium-Catalyzed Aminocarbonylation of 1,3-Dienes: Atom-Efficient Synthesis of β,γ-Unsaturated Amides

Carbonylation reactions constitute important methodologies for the synthesis of all kinds of carboxylic acid derivatives. The development of novel and efficient catalysts for these transformations is of interest for both academic and industrial research. Here, the first palladium-based catalyst syst...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2014-11, Vol.136 (45), p.16039-16043
Main Authors: Fang, Xianjie, Li, Haoquan, Jackstell, Ralf, Beller, Matthias
Format: Article
Language:English
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Summary:Carbonylation reactions constitute important methodologies for the synthesis of all kinds of carboxylic acid derivatives. The development of novel and efficient catalysts for these transformations is of interest for both academic and industrial research. Here, the first palladium-based catalyst system for the aminocarbonylation of 1,3-dienes is described. This atom-efficient transformation proceeds under additive-free conditions and provides straightforward access to a variety of β,γ-unsaturated amides in good to excellent yields, often with high selectivities.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja507530f