Prognosis in very young women with triple-negative breast cancer: retrospective study of 216 cases

The aim of this investigation was to compare clinical pathological characteristics and prognosis of very young and older triple-negative breast cancer (TNBC) patients in order to assess their relevance to TNBC in an younger population. Data of TNBC patients diagnosed between 2002 and 2007 were retro...

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Published in:Medical oncology (Northwood, London, England) London, England), 2014-12, Vol.31 (12), p.222-222, Article 222
Main Authors: Liu, Ying, Xin, Tao, Huang, Da-yong, Shen, Wei-xi, Li, Li, Lv, Yan-ju, Jin, Ying-hua, Song, Xiao-wei, Teng, Chong, Jiang, Qiu-ying
Format: Article
Language:English
Subjects:
Adult
Age Factors
Breast cancer
Female
Follow-Up Studies
Hematology
Humans
Internal Medicine
Medicine
Medicine & Public Health
Oncology
Original Paper
Pathology
Prognosis
Retrospective Studies
Survival Rate - trends
Triple Negative Breast Neoplasms - diagnosis
Triple Negative Breast Neoplasms - mortality
Young Adult
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Summary:The aim of this investigation was to compare clinical pathological characteristics and prognosis of very young and older triple-negative breast cancer (TNBC) patients in order to assess their relevance to TNBC in an younger population. Data of TNBC patients diagnosed between 2002 and 2007 were retrospectively analyzed by computer based chart information. Baseline tumor characteristics, biological markers, and patients’ prognosis were compared between very young (≤35 years) and older (>35 years) TNBC patients. In the 216 cases of operable TNBC patients, 48 (22.2 %) were ≤35 years and 168 (77.8 %) were >35 years. Very young TNBC patients had showed a high clinical stage, more positive lymph nodes, Ck5/6 and/or EGFR expression ( P  = 0.049, 0.006, and 0.011, respectively). Compared to older TNBC patients, very young TNBC patients have short disease-free survival ( P  = 0.031), while no significant difference was found in overall survival (OS) ( P  = 0.075). In multivariate analysis, lymph node metastatic status was a significant predictor of OS. TNBC of very young patients is an aggressive breast cancer subtype, but the overall survival of both young and older TNBC patients did not have significant differences.
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-014-0222-2