A systematic review and meta‐regression analysis of mivacurium for tracheal intubation

Summary We systematically reviewed factors associated with intubation conditions in randomised controlled trials of mivacurium, using random‐effects meta‐regression analysis. We included 29 studies of 1050 healthy participants. Four factors explained 72.9% of the variation in the probability of exce...

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Bibliographic Details
Published in:Anaesthesia 2014-12, Vol.69 (12), p.1377-1387
Main Authors: Vanlinthout, L. E. H., Mesfin, S. H., Hens, N., Vanacker, B. F., Robertson, E. N., Booij, L. H. D. J.
Format: Article
Language:English
Subjects:
Anesthesia
Female
Humans
Intubation
Intubation, Intratracheal - methods
Isoquinolines - administration & dosage
Male
Meta-analysis
Neuromuscular Nondepolarizing Agents - administration & dosage
Randomized Controlled Trials as Topic
Regression Analysis
Systematic review
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Summary:Summary We systematically reviewed factors associated with intubation conditions in randomised controlled trials of mivacurium, using random‐effects meta‐regression analysis. We included 29 studies of 1050 healthy participants. Four factors explained 72.9% of the variation in the probability of excellent intubation conditions: mivacurium dose, 24.4%; opioid use, 29.9%; time to intubation and age together, 18.6%. The odds ratio (95% CI) for excellent intubation was 3.14 (1.65–5.73) for doubling the mivacurium dose, 5.99 (2.14–15.18) for adding opioids to the intubation sequence, and 6.55 (6.01–7.74) for increasing the delay between mivacurium injection and airway insertion from 1 to 2 min in subjects aged 25 years and 2.17 (2.01–2.69) for subjects aged 70 years, p 
ISSN:0003-2409
1365-2044
DOI:10.1111/anae.12786