Concentration-Dependent Biphasic Effects of Resveratrol on Human Natural Killer Cells in Vitro

Resveratrol (RES) is a polyphenol phytoalexin from plants, which has been reported to possess a variety of biological effects. The properties of RES on human natural killer (NK) cells were assessed in this study. Results showed that RES has concentration-dependent biphasic effects on NK cells. In hi...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2014-11, Vol.62 (45), p.10928-10935
Main Authors: Li, Qi, Huyan, Ting, Ye, Lin-Jie, Li, Ji, Shi, Jun-Ling, Huang, Qing-Sheng
Format: Article
Language:English
Subjects:
antineoplastic agents
apoptosis
Apoptosis - drug effects
caspases
cytotoxicity
Humans
interferon-gamma
Jurkat Cells
Killer Cells, Natural - cytology
Killer Cells, Natural - drug effects
Killer Cells, Natural - immunology
messenger RNA
natural killer cells
phytoalexins
polyphenols
resveratrol
signal transduction
Signal Transduction - drug effects
Stilbenes - analysis
Stilbenes - pharmacology
viability
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Summary:Resveratrol (RES) is a polyphenol phytoalexin from plants, which has been reported to possess a variety of biological effects. The properties of RES on human natural killer (NK) cells were assessed in this study. Results showed that RES has concentration-dependent biphasic effects on NK cells. In high concentration (50 μM), RES can inhibit viability and promoted apoptosis of NK cells and human lymphoblastoid T (Jurkat) cells, which may affect the caspase signaling pathway. The Jurkat cells were more sensitive than NK cells on the RES caused cell death. However, when the concentration range reduced from 3.13 to 1.56 μM, RES showed the positive effects on NK cells by increasing the NK cells cytotoxicity via up-regulating the expression of NKG2D and IFN-γ (in mRNA and protein levels). These results indicated that one needs to pay more attention to the dosage and biphasic effects when RES was applied as antitumor drugs or health products.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf502950u