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Outcomes after curative hepatectomy in patients with non-B non-C hepatocellular carcinoma and hepatitis B virus hepatocellular carcinoma from non-cirrhotic liver
Backgrounds and Objective There is controversy regarding liver function of non‐B, non‐C hepatocellular carcinoma (NBNC‐HCC) patients, the biological behavior of their tumors, and the outcome after surgical treatment. The aims of the present study were to compare clinicopathologic data and long‐term...
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| Published in: | Journal of surgical oncology 2014-12, Vol.110 (8), p.976-981 |
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| container_issue | 8 |
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| container_title | Journal of surgical oncology |
| container_volume | 110 |
| creator | Kim, Jong Man Kwon, Choon Hyuck David Joh, Jae-Won Park, Jae Berm Lee, Joon Hyeok Kim, Sung Joo Paik, Seung Woon Park, Cheol Keun Yoo, Byung Chul |
| description | Backgrounds and Objective
There is controversy regarding liver function of non‐B, non‐C hepatocellular carcinoma (NBNC‐HCC) patients, the biological behavior of their tumors, and the outcome after surgical treatment. The aims of the present study were to compare clinicopathologic data and long‐term clinical outcomes between NBNC‐HCC patients and hepatitis B virus HCC (HBV‐HCC) patients from non‐cirrhotic liver after curative hepatectomy.
Methods
Data for HBV‐HCC patients (n = 360) and NBNC‐HCC patients (n = 103) were retrospectively reviewed.
Results
The median age of patients in the NBNC group was significantly higher than that of the HBV group (63 years vs. 53 years, P |
| doi_str_mv | 10.1002/jso.23772 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1625349654</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3492897091</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4272-550a699b721df081da4e048b93a50951139c79540c2c53dc48b34764da29f91b3</originalsourceid><addsrcrecordid>eNp1kctOGzEYhS1UBCmw6AsgS910M-DrOF6WcAc1ogXRneV4PIrDzDi1PdA8Tt8UJ0NZVOrGF53vHB39PwCfMDrCCJHjRfRHhApBtsAII1kWEsnxBzDKGimYkGgXfIxxgRCSsmQ7YJdwLDBlbAT-TPtkfGsj1HWyAZo-6OSeLZzbpU7WJN-uoOtg_jjbpQhfXJrDznfFyeacDKA3tmn6RucAHYzrfKuh7qpBdMlFeAKfXejj__E6-HYTaVwIc5-cgU0uEvbBdq2baA_e7j3wcH52P7ksbqcXV5Ovt4VhRJCCc6RLKWeC4KpGY1xpZhEbzyTVHEmOMZVGSM6QIYbTymSJMlGyShNZSzyje-DLkLsM_ldvY1Kti-ueurO-jwqXhFMmS84y-vkfdOH70OV2a4pIlueLMnX4RvWz1lZqGVyrw0r9HX4GjgfgxTV29a5jpNZbVXmrarNVdf1junlkRzE4XEz297tDhydVCiq4evx2ob6L0593hN-oU_oKqculRg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1622942510</pqid></control><display><type>article</type><title>Outcomes after curative hepatectomy in patients with non-B non-C hepatocellular carcinoma and hepatitis B virus hepatocellular carcinoma from non-cirrhotic liver</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Kim, Jong Man ; Kwon, Choon Hyuck David ; Joh, Jae-Won ; Park, Jae Berm ; Lee, Joon Hyeok ; Kim, Sung Joo ; Paik, Seung Woon ; Park, Cheol Keun ; Yoo, Byung Chul</creator><creatorcontrib>Kim, Jong Man ; Kwon, Choon Hyuck David ; Joh, Jae-Won ; Park, Jae Berm ; Lee, Joon Hyeok ; Kim, Sung Joo ; Paik, Seung Woon ; Park, Cheol Keun ; Yoo, Byung Chul</creatorcontrib><description>Backgrounds and Objective
There is controversy regarding liver function of non‐B, non‐C hepatocellular carcinoma (NBNC‐HCC) patients, the biological behavior of their tumors, and the outcome after surgical treatment. The aims of the present study were to compare clinicopathologic data and long‐term clinical outcomes between NBNC‐HCC patients and hepatitis B virus HCC (HBV‐HCC) patients from non‐cirrhotic liver after curative hepatectomy.
Methods
Data for HBV‐HCC patients (n = 360) and NBNC‐HCC patients (n = 103) were retrospectively reviewed.
Results
The median age of patients in the NBNC group was significantly higher than that of the HBV group (63 years vs. 53 years, P < 0.001). Tumor size in the NBNC group was greater than that in the HBV group (5.1 cm vs. 3.8 cm, P < 0.001). Regarding liver histology, the grade of lobular activity, periportal activity, and fibrosis in the HBV group was higher than in the NBNC group (P < 0.001, P < 0.001, and P < 0.001, respectively). There were no statistically significant differences in disease‐free survival and overall survival between the two groups (P = 0.257 and P = 0.579, respectively). Multivariate analysis showed that increased tumor size, microvascular invasion, and intrahepatic metastasis were associated with tumor recurrence after curative liver resection.
Conclusion
For patients with non‐cirrhotic liver, clinical outcomes for NBNC‐HCC were comparable to those for HBV‐HCC after curative hepatectomy. J. Surg. Oncol. 2014; 110:976–981. © 2014 Wiley Periodicals, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.23772</identifier><identifier>PMID: 25171344</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Disease-Free Survival ; Female ; Hepatectomy ; Hepatitis B - complications ; hepatitis B virus ; hepatocellular carcinoma ; Humans ; Liver Neoplasms - mortality ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Male ; Middle Aged ; non B non C ; non-cirrhosis ; prognosis ; survival ; Treatment Outcome ; tumor recurrence ; tumor size</subject><ispartof>Journal of surgical oncology, 2014-12, Vol.110 (8), p.976-981</ispartof><rights>2014 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4272-550a699b721df081da4e048b93a50951139c79540c2c53dc48b34764da29f91b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25171344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Jong Man</creatorcontrib><creatorcontrib>Kwon, Choon Hyuck David</creatorcontrib><creatorcontrib>Joh, Jae-Won</creatorcontrib><creatorcontrib>Park, Jae Berm</creatorcontrib><creatorcontrib>Lee, Joon Hyeok</creatorcontrib><creatorcontrib>Kim, Sung Joo</creatorcontrib><creatorcontrib>Paik, Seung Woon</creatorcontrib><creatorcontrib>Park, Cheol Keun</creatorcontrib><creatorcontrib>Yoo, Byung Chul</creatorcontrib><title>Outcomes after curative hepatectomy in patients with non-B non-C hepatocellular carcinoma and hepatitis B virus hepatocellular carcinoma from non-cirrhotic liver</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Backgrounds and Objective
There is controversy regarding liver function of non‐B, non‐C hepatocellular carcinoma (NBNC‐HCC) patients, the biological behavior of their tumors, and the outcome after surgical treatment. The aims of the present study were to compare clinicopathologic data and long‐term clinical outcomes between NBNC‐HCC patients and hepatitis B virus HCC (HBV‐HCC) patients from non‐cirrhotic liver after curative hepatectomy.
Methods
Data for HBV‐HCC patients (n = 360) and NBNC‐HCC patients (n = 103) were retrospectively reviewed.
Results
The median age of patients in the NBNC group was significantly higher than that of the HBV group (63 years vs. 53 years, P < 0.001). Tumor size in the NBNC group was greater than that in the HBV group (5.1 cm vs. 3.8 cm, P < 0.001). Regarding liver histology, the grade of lobular activity, periportal activity, and fibrosis in the HBV group was higher than in the NBNC group (P < 0.001, P < 0.001, and P < 0.001, respectively). There were no statistically significant differences in disease‐free survival and overall survival between the two groups (P = 0.257 and P = 0.579, respectively). Multivariate analysis showed that increased tumor size, microvascular invasion, and intrahepatic metastasis were associated with tumor recurrence after curative liver resection.
Conclusion
For patients with non‐cirrhotic liver, clinical outcomes for NBNC‐HCC were comparable to those for HBV‐HCC after curative hepatectomy. J. Surg. Oncol. 2014; 110:976–981. © 2014 Wiley Periodicals, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Hepatectomy</subject><subject>Hepatitis B - complications</subject><subject>hepatitis B virus</subject><subject>hepatocellular carcinoma</subject><subject>Humans</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>non B non C</subject><subject>non-cirrhosis</subject><subject>prognosis</subject><subject>survival</subject><subject>Treatment Outcome</subject><subject>tumor recurrence</subject><subject>tumor size</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp1kctOGzEYhS1UBCmw6AsgS910M-DrOF6WcAc1ogXRneV4PIrDzDi1PdA8Tt8UJ0NZVOrGF53vHB39PwCfMDrCCJHjRfRHhApBtsAII1kWEsnxBzDKGimYkGgXfIxxgRCSsmQ7YJdwLDBlbAT-TPtkfGsj1HWyAZo-6OSeLZzbpU7WJN-uoOtg_jjbpQhfXJrDznfFyeacDKA3tmn6RucAHYzrfKuh7qpBdMlFeAKfXejj__E6-HYTaVwIc5-cgU0uEvbBdq2baA_e7j3wcH52P7ksbqcXV5Ovt4VhRJCCc6RLKWeC4KpGY1xpZhEbzyTVHEmOMZVGSM6QIYbTymSJMlGyShNZSzyje-DLkLsM_ldvY1Kti-ueurO-jwqXhFMmS84y-vkfdOH70OV2a4pIlueLMnX4RvWz1lZqGVyrw0r9HX4GjgfgxTV29a5jpNZbVXmrarNVdf1junlkRzE4XEz297tDhydVCiq4evx2ob6L0593hN-oU_oKqculRg</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Kim, Jong Man</creator><creator>Kwon, Choon Hyuck David</creator><creator>Joh, Jae-Won</creator><creator>Park, Jae Berm</creator><creator>Lee, Joon Hyeok</creator><creator>Kim, Sung Joo</creator><creator>Paik, Seung Woon</creator><creator>Park, Cheol Keun</creator><creator>Yoo, Byung Chul</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20141201</creationdate><title>Outcomes after curative hepatectomy in patients with non-B non-C hepatocellular carcinoma and hepatitis B virus hepatocellular carcinoma from non-cirrhotic liver</title><author>Kim, Jong Man ; Kwon, Choon Hyuck David ; Joh, Jae-Won ; Park, Jae Berm ; Lee, Joon Hyeok ; Kim, Sung Joo ; Paik, Seung Woon ; Park, Cheol Keun ; Yoo, Byung Chul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4272-550a699b721df081da4e048b93a50951139c79540c2c53dc48b34764da29f91b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Hepatectomy</topic><topic>Hepatitis B - complications</topic><topic>hepatitis B virus</topic><topic>hepatocellular carcinoma</topic><topic>Humans</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>non B non C</topic><topic>non-cirrhosis</topic><topic>prognosis</topic><topic>survival</topic><topic>Treatment Outcome</topic><topic>tumor recurrence</topic><topic>tumor size</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Jong Man</creatorcontrib><creatorcontrib>Kwon, Choon Hyuck David</creatorcontrib><creatorcontrib>Joh, Jae-Won</creatorcontrib><creatorcontrib>Park, Jae Berm</creatorcontrib><creatorcontrib>Lee, Joon Hyeok</creatorcontrib><creatorcontrib>Kim, Sung Joo</creatorcontrib><creatorcontrib>Paik, Seung Woon</creatorcontrib><creatorcontrib>Park, Cheol Keun</creatorcontrib><creatorcontrib>Yoo, Byung Chul</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Jong Man</au><au>Kwon, Choon Hyuck David</au><au>Joh, Jae-Won</au><au>Park, Jae Berm</au><au>Lee, Joon Hyeok</au><au>Kim, Sung Joo</au><au>Paik, Seung Woon</au><au>Park, Cheol Keun</au><au>Yoo, Byung Chul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes after curative hepatectomy in patients with non-B non-C hepatocellular carcinoma and hepatitis B virus hepatocellular carcinoma from non-cirrhotic liver</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>110</volume><issue>8</issue><spage>976</spage><epage>981</epage><pages>976-981</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Backgrounds and Objective
There is controversy regarding liver function of non‐B, non‐C hepatocellular carcinoma (NBNC‐HCC) patients, the biological behavior of their tumors, and the outcome after surgical treatment. The aims of the present study were to compare clinicopathologic data and long‐term clinical outcomes between NBNC‐HCC patients and hepatitis B virus HCC (HBV‐HCC) patients from non‐cirrhotic liver after curative hepatectomy.
Methods
Data for HBV‐HCC patients (n = 360) and NBNC‐HCC patients (n = 103) were retrospectively reviewed.
Results
The median age of patients in the NBNC group was significantly higher than that of the HBV group (63 years vs. 53 years, P < 0.001). Tumor size in the NBNC group was greater than that in the HBV group (5.1 cm vs. 3.8 cm, P < 0.001). Regarding liver histology, the grade of lobular activity, periportal activity, and fibrosis in the HBV group was higher than in the NBNC group (P < 0.001, P < 0.001, and P < 0.001, respectively). There were no statistically significant differences in disease‐free survival and overall survival between the two groups (P = 0.257 and P = 0.579, respectively). Multivariate analysis showed that increased tumor size, microvascular invasion, and intrahepatic metastasis were associated with tumor recurrence after curative liver resection.
Conclusion
For patients with non‐cirrhotic liver, clinical outcomes for NBNC‐HCC were comparable to those for HBV‐HCC after curative hepatectomy. J. Surg. Oncol. 2014; 110:976–981. © 2014 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25171344</pmid><doi>10.1002/jso.23772</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of surgical oncology, 2014-12, Vol.110 (8), p.976-981 |
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| subjects | Adult Aged Aged, 80 and over Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Disease-Free Survival Female Hepatectomy Hepatitis B - complications hepatitis B virus hepatocellular carcinoma Humans Liver Neoplasms - mortality Liver Neoplasms - pathology Liver Neoplasms - surgery Male Middle Aged non B non C non-cirrhosis prognosis survival Treatment Outcome tumor recurrence tumor size |
| title | Outcomes after curative hepatectomy in patients with non-B non-C hepatocellular carcinoma and hepatitis B virus hepatocellular carcinoma from non-cirrhotic liver |
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