Anti-inflammatory activity in mice of extracts from mediterranean marine invertebrates

The effects of dichloromethane and methanol extracts from the marine invertebrates Leptogorgia ceratophyta, Holothuria tubulosa, Coscinasterias tenuispina and Phallusia fumigata on carrageenan-induced paw oedema in mice were investigated. The dichloromethane extract of Coscinasterias tenuispina and...

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Bibliographic Details
Published in:Life sciences (1973) 1998, Vol.62 (9), p.PL115-PL120
Main Authors: Herencia, F., Ubeda, A., Ferrándiz, M.L., Terencio, M.C., Alcaraz, M.J., García-Carrascosa, M., Capaccioni, R., Payá, M.
Format: Article
Language:English
Subjects:
Animals
anti-inflammatory activity
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Carrageenan - toxicity
carrageenan paw edema
Coscinasterias tenuispina
cyclo-oxygenase
dichloromethane
Dinoprostone - antagonists & inhibitors
Edema - chemically induced
elastase
Female
Holothuria tubulosa
Indomethacin - pharmacology
inflammation
Invertebrates - chemistry
Leptogorgia ceratophyta
Marine Biology
marine invertebrates
methanol extracts
Mice
Muridae
Pancreatic Elastase - antagonists & inhibitors
Phallusia fumigata
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Summary:The effects of dichloromethane and methanol extracts from the marine invertebrates Leptogorgia ceratophyta, Holothuria tubulosa, Coscinasterias tenuispina and Phallusia fumigata on carrageenan-induced paw oedema in mice were investigated. The dichloromethane extract of Coscinasterias tenuispina and the methanol extract of Holothuria tubulosa administered p.o. at 50, 100 and 150 mg/kg, inhibited oedema in a dose-dependent manner 3 h after administration of carrageenan. Both extracts partially decreased elastase activity and PGE 2 levels measured in homogenates from inflamed paws, without affecting the levels of this prostanoid present in stomach homogenates. As observed with the selective inhibitor NS398, both extracts can decrease cyclo-oxygenase activity in inflamed tissues but do not modify the constitutive cyclo-oxygenase enzyme. Therefore, these extracts represent new marine resources for the isolation of novel agents active on inflammatory conditions.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(97)01188-0