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Anti-inflammatory activity in mice of extracts from mediterranean marine invertebrates
The effects of dichloromethane and methanol extracts from the marine invertebrates Leptogorgia ceratophyta, Holothuria tubulosa, Coscinasterias tenuispina and Phallusia fumigata on carrageenan-induced paw oedema in mice were investigated. The dichloromethane extract of Coscinasterias tenuispina and...
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| Published in: | Life sciences (1973) 1998, Vol.62 (9), p.PL115-PL120 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c457t-222d14ea14cc8dedbaf52e1f843197cba5c8cc383df957f3bb6e0b3d9eca9d623 |
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| cites | cdi_FETCH-LOGICAL-c457t-222d14ea14cc8dedbaf52e1f843197cba5c8cc383df957f3bb6e0b3d9eca9d623 |
| container_end_page | PL120 |
| container_issue | 9 |
| container_start_page | PL115 |
| container_title | Life sciences (1973) |
| container_volume | 62 |
| creator | Herencia, F. Ubeda, A. Ferrándiz, M.L. Terencio, M.C. Alcaraz, M.J. García-Carrascosa, M. Capaccioni, R. Payá, M. |
| description | The effects of dichloromethane and methanol extracts from the marine invertebrates
Leptogorgia ceratophyta, Holothuria tubulosa, Coscinasterias tenuispina and
Phallusia fumigata on carrageenan-induced paw oedema in mice were investigated. The dichloromethane extract of
Coscinasterias tenuispina and the methanol extract of
Holothuria tubulosa administered
p.o. at 50, 100 and 150 mg/kg, inhibited oedema in a dose-dependent manner 3 h after administration of carrageenan. Both extracts partially decreased elastase activity and PGE
2 levels measured in homogenates from inflamed paws, without affecting the levels of this prostanoid present in stomach homogenates. As observed with the selective inhibitor NS398, both extracts can decrease cyclo-oxygenase activity in inflamed tissues but do not modify the constitutive cyclo-oxygenase enzyme. Therefore, these extracts represent new marine resources for the isolation of novel agents active on inflammatory conditions. |
| doi_str_mv | 10.1016/S0024-3205(97)01188-0 |
| format | article |
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Leptogorgia ceratophyta, Holothuria tubulosa, Coscinasterias tenuispina and
Phallusia fumigata on carrageenan-induced paw oedema in mice were investigated. The dichloromethane extract of
Coscinasterias tenuispina and the methanol extract of
Holothuria tubulosa administered
p.o. at 50, 100 and 150 mg/kg, inhibited oedema in a dose-dependent manner 3 h after administration of carrageenan. Both extracts partially decreased elastase activity and PGE
2 levels measured in homogenates from inflamed paws, without affecting the levels of this prostanoid present in stomach homogenates. As observed with the selective inhibitor NS398, both extracts can decrease cyclo-oxygenase activity in inflamed tissues but do not modify the constitutive cyclo-oxygenase enzyme. Therefore, these extracts represent new marine resources for the isolation of novel agents active on inflammatory conditions.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/S0024-3205(97)01188-0</identifier><identifier>PMID: 9496704</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; anti-inflammatory activity ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Carrageenan - toxicity ; carrageenan paw edema ; Coscinasterias tenuispina ; cyclo-oxygenase ; dichloromethane ; Dinoprostone - antagonists & inhibitors ; Edema - chemically induced ; elastase ; Female ; Holothuria tubulosa ; Indomethacin - pharmacology ; inflammation ; Invertebrates - chemistry ; Leptogorgia ceratophyta ; Marine Biology ; marine invertebrates ; methanol extracts ; Mice ; Muridae ; Pancreatic Elastase - antagonists & inhibitors ; Phallusia fumigata</subject><ispartof>Life sciences (1973), 1998, Vol.62 (9), p.PL115-PL120</ispartof><rights>1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-222d14ea14cc8dedbaf52e1f843197cba5c8cc383df957f3bb6e0b3d9eca9d623</citedby><cites>FETCH-LOGICAL-c457t-222d14ea14cc8dedbaf52e1f843197cba5c8cc383df957f3bb6e0b3d9eca9d623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9496704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herencia, F.</creatorcontrib><creatorcontrib>Ubeda, A.</creatorcontrib><creatorcontrib>Ferrándiz, M.L.</creatorcontrib><creatorcontrib>Terencio, M.C.</creatorcontrib><creatorcontrib>Alcaraz, M.J.</creatorcontrib><creatorcontrib>García-Carrascosa, M.</creatorcontrib><creatorcontrib>Capaccioni, R.</creatorcontrib><creatorcontrib>Payá, M.</creatorcontrib><title>Anti-inflammatory activity in mice of extracts from mediterranean marine invertebrates</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>The effects of dichloromethane and methanol extracts from the marine invertebrates
Leptogorgia ceratophyta, Holothuria tubulosa, Coscinasterias tenuispina and
Phallusia fumigata on carrageenan-induced paw oedema in mice were investigated. The dichloromethane extract of
Coscinasterias tenuispina and the methanol extract of
Holothuria tubulosa administered
p.o. at 50, 100 and 150 mg/kg, inhibited oedema in a dose-dependent manner 3 h after administration of carrageenan. Both extracts partially decreased elastase activity and PGE
2 levels measured in homogenates from inflamed paws, without affecting the levels of this prostanoid present in stomach homogenates. As observed with the selective inhibitor NS398, both extracts can decrease cyclo-oxygenase activity in inflamed tissues but do not modify the constitutive cyclo-oxygenase enzyme. Therefore, these extracts represent new marine resources for the isolation of novel agents active on inflammatory conditions.</description><subject>Animals</subject><subject>anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Carrageenan - toxicity</subject><subject>carrageenan paw edema</subject><subject>Coscinasterias tenuispina</subject><subject>cyclo-oxygenase</subject><subject>dichloromethane</subject><subject>Dinoprostone - antagonists & inhibitors</subject><subject>Edema - chemically induced</subject><subject>elastase</subject><subject>Female</subject><subject>Holothuria tubulosa</subject><subject>Indomethacin - pharmacology</subject><subject>inflammation</subject><subject>Invertebrates - chemistry</subject><subject>Leptogorgia ceratophyta</subject><subject>Marine Biology</subject><subject>marine invertebrates</subject><subject>methanol extracts</subject><subject>Mice</subject><subject>Muridae</subject><subject>Pancreatic Elastase - antagonists & inhibitors</subject><subject>Phallusia fumigata</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFkElLAzEUgIMotVZ_QmFOoofRZDLJJCcpxQ0KHlyuIZN5gcgsNUmL_femC716evDe97YPoSnBdwQTfv-OcVHmtMDsRla3mBAhcnyCxkRUMsecklM0PiLn6CKEb4wxYxUdoZEsJa9wOUZfsz663PW21V2n4-A3mTbRrV3cZK7POmcgG2wGv9GnfMisH7qsg8ZF8F73oBOjvesh0WvwEWqvI4RLdGZ1G-DqECfo8-nxY_6SL96eX-ezRW5KVsW8KIqGlKBJaYxooKm1ZQUQK0pKZGVqzYwwhgraWMkqS-uaA65pI8Fo2fCCTtD1fu7SDz8rCFF1Lhho23TasAqK8IJxQXkC2R40fgjBg1VL79LlG0Ww2vpUO59qK0vJSu18Kpz6pocFqzq9few6CEz1h30d0pdrB14F46A3yZAHE1UzuH82_AGsHYdj</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Herencia, F.</creator><creator>Ubeda, A.</creator><creator>Ferrándiz, M.L.</creator><creator>Terencio, M.C.</creator><creator>Alcaraz, M.J.</creator><creator>García-Carrascosa, M.</creator><creator>Capaccioni, R.</creator><creator>Payá, M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope></search><sort><creationdate>1998</creationdate><title>Anti-inflammatory activity in mice of extracts from mediterranean marine invertebrates</title><author>Herencia, F. ; Ubeda, A. ; Ferrándiz, M.L. ; Terencio, M.C. ; Alcaraz, M.J. ; García-Carrascosa, M. ; Capaccioni, R. ; Payá, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-222d14ea14cc8dedbaf52e1f843197cba5c8cc383df957f3bb6e0b3d9eca9d623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Carrageenan - toxicity</topic><topic>carrageenan paw edema</topic><topic>Coscinasterias tenuispina</topic><topic>cyclo-oxygenase</topic><topic>dichloromethane</topic><topic>Dinoprostone - antagonists & inhibitors</topic><topic>Edema - chemically induced</topic><topic>elastase</topic><topic>Female</topic><topic>Holothuria tubulosa</topic><topic>Indomethacin - pharmacology</topic><topic>inflammation</topic><topic>Invertebrates - chemistry</topic><topic>Leptogorgia ceratophyta</topic><topic>Marine Biology</topic><topic>marine invertebrates</topic><topic>methanol extracts</topic><topic>Mice</topic><topic>Muridae</topic><topic>Pancreatic Elastase - antagonists & inhibitors</topic><topic>Phallusia fumigata</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herencia, F.</creatorcontrib><creatorcontrib>Ubeda, A.</creatorcontrib><creatorcontrib>Ferrándiz, M.L.</creatorcontrib><creatorcontrib>Terencio, M.C.</creatorcontrib><creatorcontrib>Alcaraz, M.J.</creatorcontrib><creatorcontrib>García-Carrascosa, M.</creatorcontrib><creatorcontrib>Capaccioni, R.</creatorcontrib><creatorcontrib>Payá, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herencia, F.</au><au>Ubeda, A.</au><au>Ferrándiz, M.L.</au><au>Terencio, M.C.</au><au>Alcaraz, M.J.</au><au>García-Carrascosa, M.</au><au>Capaccioni, R.</au><au>Payá, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory activity in mice of extracts from mediterranean marine invertebrates</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1998</date><risdate>1998</risdate><volume>62</volume><issue>9</issue><spage>PL115</spage><epage>PL120</epage><pages>PL115-PL120</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>The effects of dichloromethane and methanol extracts from the marine invertebrates
Leptogorgia ceratophyta, Holothuria tubulosa, Coscinasterias tenuispina and
Phallusia fumigata on carrageenan-induced paw oedema in mice were investigated. The dichloromethane extract of
Coscinasterias tenuispina and the methanol extract of
Holothuria tubulosa administered
p.o. at 50, 100 and 150 mg/kg, inhibited oedema in a dose-dependent manner 3 h after administration of carrageenan. Both extracts partially decreased elastase activity and PGE
2 levels measured in homogenates from inflamed paws, without affecting the levels of this prostanoid present in stomach homogenates. As observed with the selective inhibitor NS398, both extracts can decrease cyclo-oxygenase activity in inflamed tissues but do not modify the constitutive cyclo-oxygenase enzyme. Therefore, these extracts represent new marine resources for the isolation of novel agents active on inflammatory conditions.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>9496704</pmid><doi>10.1016/S0024-3205(97)01188-0</doi></addata></record> |
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| ispartof | Life sciences (1973), 1998, Vol.62 (9), p.PL115-PL120 |
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| language | eng |
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| subjects | Animals anti-inflammatory activity Anti-Inflammatory Agents, Non-Steroidal - pharmacology Carrageenan - toxicity carrageenan paw edema Coscinasterias tenuispina cyclo-oxygenase dichloromethane Dinoprostone - antagonists & inhibitors Edema - chemically induced elastase Female Holothuria tubulosa Indomethacin - pharmacology inflammation Invertebrates - chemistry Leptogorgia ceratophyta Marine Biology marine invertebrates methanol extracts Mice Muridae Pancreatic Elastase - antagonists & inhibitors Phallusia fumigata |
| title | Anti-inflammatory activity in mice of extracts from mediterranean marine invertebrates |
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