Effect of an immunomodulating agent, RU 41740, on polymorphonuclear responsiveness after burn injury

An impairment of polymorphonuclear leukocyte (PMN) functions has been described following burn trauma. It was thus of interest to investigate the effect of RU 41740, an agent known to stimulate these cells, on rat PMN functions after burn injury. In the present study the responsiveness to classical...

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Bibliographic Details
Published in:Inflammation 1991-12, Vol.15 (6), p.437-445
Main Authors: ROCH-ARVEILLER, M, FONTAGNE, J, EL ABBOUYI, A, RAICHVARG, D, GIROUD, J. P
Format: Article
Language:English
Subjects:
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Inflammation
Molecular and cellular biology
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Summary:An impairment of polymorphonuclear leukocyte (PMN) functions has been described following burn trauma. It was thus of interest to investigate the effect of RU 41740, an agent known to stimulate these cells, on rat PMN functions after burn injury. In the present study the responsiveness to classical stimuli of PMN from untreated burned rats was approximately 40% lower than healthy control values. In vitro treatment with RU 41740 increased oxidative metabolism of PMNs from burned and healthy rats. The effect was dose-related but was most striking in the case of PMNs from healthy rats. The maximal effective dose was 10 mg/kg/day in both cases. In contrast, 25 and 50 mg/kg/day doses inhibited PMN oxidative metabolism.
ISSN:0360-3997
1573-2576
DOI:10.1007/BF00923341