Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey

We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentatio...

Full description

Saved in:
Bibliographic Details
Published in:Brain research 1998-03, Vol.787 (1), p.157-160
Main Authors: Boraud, Th, Bezard, E, Guehl, D, Bioulac, B, Gross, Ch
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dopamine Agents - toxicity
Female
Globus Pallidus - cytology
Globus Pallidus - drug effects
Immunohistochemistry
l-DOPA
Levodopa - pharmacology
Macaca mulatta
Medical sciences
MPTP Poisoning
MPTP-treated monkey
Neurology
Neurons - drug effects
Parkinson Disease, Secondary - chemically induced
Parkinson Disease, Secondary - drug therapy
Parkinson Disease, Secondary - pathology
Parkinson's disease
Unit recordings of the globus pallidus (GPe, GPi)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During l-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of l-DOPA on GPi output is limited.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(97)01563-1