Local manganese chloride treatment accelerates fracture healing in a rat model

ABSTRACT This study investigated the effects of local delivery of manganese chloride (MnCl2), an insulin‐mimetic compound, upon fracture healing using a rat femoral fracture model. Mechanical testing, histomorphometry, and immunohistochemistry were performed to assess early and late parameters of fr...

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Bibliographic Details
Published in:Journal of orthopaedic research 2015-01, Vol.33 (1), p.122-130
Main Authors: Hreha, Jeremy, Wey, Aaron, Cunningham, Catherine, Krell, Ethan S., Brietbart, Eric A., Paglia, David N., Montemurro, Nicholas J., Nguyen, Daniel A., Lee, Yung-Jae, Komlos, Daniel, Lim, Elisha, Benevenia, Joseph, O'Connor, J. Patrick, Lin, Sheldon S.
Format: Article
Language:English
Subjects:
Actins - metabolism
Animals
Biomechanical Phenomena
bone regeneration
Chlorides - pharmacology
Chlorides - therapeutic use
Female
Femoral Fractures - drug therapy
Femoral Fractures - metabolism
fracture healing
Fracture Healing - drug effects
insulin-mimetic
Male
manganese chloride
Manganese Compounds - pharmacology
Manganese Compounds - therapeutic use
Models, Animal
Neovascularization, Physiologic - drug effects
Platelet Endothelial Cell Adhesion Molecule-1 - metabolism
rat
Rats
Rats, Inbred BB
Rats, Wistar
Treatment Outcome
Vascular Endothelial Growth Factor A - metabolism
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Summary:ABSTRACT This study investigated the effects of local delivery of manganese chloride (MnCl2), an insulin‐mimetic compound, upon fracture healing using a rat femoral fracture model. Mechanical testing, histomorphometry, and immunohistochemistry were performed to assess early and late parameters of fracture healing. At 4 weeks post‐fracture, maximum torque to failure was 70% higher (P 
ISSN:0736-0266
1554-527X
DOI:10.1002/jor.22733