Location, extent, and multifocality of positive surgical margins for biochemical recurrence prediction after radical prostatectomy

• Published in: World journal of urology 2014-12, Vol.32 (6), p.1393-1400
• Main Authors: Ploussard, Guillaume, Drouin, Sarah J., Rode, Julie, Allory, Yves, Vordos, Dimitri, Hoznek, Andras, Abbou, Claude-Clément, de la Taille, Alexandre, Salomon, Laurent
• Format: Article
• Language: English
• Subjects: Aged; Cohort Studies; Disease-Free Survival; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Recurrence, Local - blood; Neoplasm Recurrence, Local - diagnosis; Nephrology; Oncology; Original Article; Predictive Value of Tests; Proportional Hazards Models; Prostate-Specific Antigen - blood; Prostatectomy; Prostatic Neoplasms - blood; Prostatic Neoplasms - pathology; Prostatic Neoplasms - surgery; Urology
• ISSN: 0724-4983; 1433-8726
• DOI: 10.1007/s00345-014-1243-3

Purpose To study the prognostic value of extent, number, and location of positive surgical margins (PSM). Methods A total of 1,504 consecutive adjuvant treatment naive and node-negative radical prostatectomy men were included in a prospective database including extent, number, and location of PSM. Mean follow-up was 33 months. Endpoint was biochemical progression-free (bPFS) survival. The impact of margin status and characteristics was assessed in time-dependent analyses using Cox regression and Kaplan–Meier methods. Results PSM was reported in 26.7 % of patients. The predominant PSM locations were apex and posterior locations. Median PSM length was 4.0 mm. The 2-year bPFS was 73.7 % in PSM patients as compared to 93.0 % in NSM patients ( p