Relationship Between Sniff Nasal Inspiratory Pressure and BODE Index in Patients with COPD

• Published in: Lung 2014-12, Vol.192 (6), p.897-903
• Main Authors: Donária, Leila, Mesquita, Rafael, Martinez, Larissa, Sípoli, Luciana, Felcar, Josiane Marques, Probst, Vanessa Suziane, Hernandes, Nidia Aparecida, Pitta, Fabio
• Format: Article
• Language: English
• Subjects: Aged; Analysis of Variance; Body Mass Index; Brazil; Chronic obstructive lung disease; Chronic obstructive pulmonary disease; Complications and side effects; Cross-Sectional Studies; Development and progression; Evaluation Studies as Topic; Exercise; Exercise Test - methods; Exercise Tolerance - physiology; Female; Forced Expiratory Volume - physiology; Humans; Inhalation - physiology; Inspiratory Capacity - physiology; Lung diseases, Obstructive; Male; Measurement; Medical tests; Medicine; Medicine & Public Health; Middle Aged; Muscle strength; Muscle Strength - physiology; Muscular system; Nasal Cavity - physiopathology; Patient outcomes; Physiological aspects; Pneumology/Respiratory System; Predictive Value of Tests; Pressure; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - mortality; Pulmonary Disease, Chronic Obstructive - physiopathology; Respiration; Respiratory Muscles - physiopathology; Respiratory system; Risk Assessment; Risk factors; Sensitivity and Specificity; Severity of Illness Index; Survival Rate
• ISSN: 0341-2040; 1432-1750
• DOI: 10.1007/s00408-014-9649-7

Purpose The aims of this study were to investigate the relationship between sniff nasal inspiratory pressure (SNIP) and severity of chronic obstructive pulmonary disease (COPD) as defined by the BODE index, and to investigate the capacity of different SNIP cutoffs to predict a BODE index score ≥5 (i.e., worse disease severity). Methods Thirty-eight subjects with COPD (21 men, 66 ± 8 years, forced expiratory volume in the first second (FEV 1 ) 42 ± 16 % predicted) underwent assessments of SNIP, airflow limitation, body mass index (BMI), dyspnea (Medical Research Council scale), and exercise capacity (6-min walking test, 6MWT). The BODE index was calculated, and patients were separated into two groups according to the BODE quartiles (1 and 2, or 3 and 4). Results Patients from quartiles 3 and 4 presented lower values of SNIP than patients from quartiles 1 and 2 (73 ± 18 vs 56 ± 21 cmH 2 O, respectively; p  = 0.01). There was significant and inverse correlation between SNIP and the BODE index ( r  = −0.62; p