Copper-Mediated α‑Trifluoromethylation of N‑Phenylcinnamamides Coupled with Dearomatization: Access to Trifluoromethylated 1‑Azaspiro[4.5]decanes

Copper-mediated intramolecular trifluoromethylation of N-phenylcinnamamides coupled with cyclization and dearomatization was used to construct various trifluoromethylated 1-azaspiro[4.5]decanes in moderate to high yields and with excellent regioselectivity and diastereoselectivity.

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Bibliographic Details
Published in:Organic letters 2014-11, Vol.16 (22), p.5914-5917
Main Authors: Han, Guifang, Wang, Qiang, Liu, Yuxiu, Wang, Qingmin
Format: Article
Language:English
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Summary:Copper-mediated intramolecular trifluoromethylation of N-phenylcinnamamides coupled with cyclization and dearomatization was used to construct various trifluoromethylated 1-azaspiro[4.5]decanes in moderate to high yields and with excellent regioselectivity and diastereoselectivity.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol502921a