Both membrane stretch and fatty acids directly activate large conductance Ca super(2+)-activated K super(+) channels in vascular smooth muscle cells

Large conductance Ca super(2+)-activated K super(+) channels in rabbit pulmonary artery smooth muscle cells are activated by membrane stretch and by arachidonic acid and other fatty acids. Activation by stretch appears to occur by a direct effect of stretch on the channel itself or a closely associa...

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Bibliographic Details
Published in:FEBS letters 1992-01, Vol.297 (1-2), p.24-28
Main Authors: Kirber, M T, Ordway, R W, Clapp, L H, Walsh, JV Jr, Singer, J J
Format: Article
Language:English
Subjects:
activation
blood vessels
channels
fatty acids
potassium
rabbits
smooth muscle
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Summary:Large conductance Ca super(2+)-activated K super(+) channels in rabbit pulmonary artery smooth muscle cells are activated by membrane stretch and by arachidonic acid and other fatty acids. Activation by stretch appears to occur by a direct effect of stretch on the channel itself or a closely associated component. In excised inside-out patches stretch activation was seen under conditions which precluded possible mechanisms involving cytosolic factors, release of Ca super(2+) from intracellular stores, or stretch induced transmembrane flux of Ca super(2+) or other ions potentially capable of activating the channel. Fatty acids also directly activate this channel. Like stretch activation, fatty acid occurs in excised inside-out patches in the absence of cytosolic constituents.
ISSN:0014-5793