Therapeutic drug monitoring of systemic antifungal therapy

The use of systemic antifungal therapy has significantly increased in recent years. Individualization of antifungal therapy through the use of serum or plasma concentrations has been suggested, although no specific recommendations have been developed. The important criteria for therapeutic drug moni...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1997-12, Vol.40 (6), p.753-764
Main Authors: SUMMERS, K. K, HARDIN, T. C, GORE, S. J, GRAYBILL, J. R
Format: Article
Language:English
Subjects:
Amphotericin B - blood
Amphotericin B - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - blood
Antifungal Agents - therapeutic use
Biological and medical sciences
Drug Monitoring
Flucytosine - blood
Flucytosine - therapeutic use
Humans
Itraconazole - blood
Itraconazole - therapeutic use
Medical sciences
Mycoses - blood
Mycoses - drug therapy
Pharmacology. Drug treatments
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The use of systemic antifungal therapy has significantly increased in recent years. Individualization of antifungal therapy through the use of serum or plasma concentrations has been suggested, although no specific recommendations have been developed. The important criteria for therapeutic drug monitoring and which of these criteria are satisfied by systemic antifungal agents are presented in this review. No one antifungal is ideally suited for application of therapeutic drug monitoring, but, under certain circumstances, obtaining serum or plasma concentrations can be justified. In patients who are susceptible to flucytosine toxicity, serum flucytosine concentrations should be monitored in an effort to avoid untoward side-effects. In contrast, therapeutic drug monitoring of amphotericin B is not recommended in the clinical setting. Demonstrating that ketoconazole and itraconazole are reaching the systemic circulation by obtaining serum concentrations may be clinically useful due to the large variability in their absorption and issues of patient compliance which may be seen with these agents. The bioavailability of fluconazole is much less varied although validation of compliance is a situation where obtaining serum concentrations may provide additional information.
ISSN:0305-7453
1460-2091
1460-2091
DOI:10.1093/jac/40.6.753