Indirect application of near infrared light induces neuroprotection in a mouse model of parkinsonism – An abscopal neuroprotective effect

Highlights • Near infrared light (NIr), directed transcranially, is neuroprotective in rodent models of neurodegeneration. • We assessed the neuroprotective efficacy of remotely-applied NIr in an MPTP mouse model of parkinsonism. • As with transcranial NIr, remote NIr protects dopaminergic cells fro...

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Bibliographic Details
Published in:Neuroscience 2014-08, Vol.274, p.93-101
Main Authors: Johnstone, D.M, el Massri, N, Moro, C, Spana, S, Wang, X.S, Torres, N, Chabrol, C, De Jaeger, X, Reinhart, F, Purushothuman, S, Benabid, A.-L, Stone, J, Mitrofanis, J
Format: Article
Language:English
Subjects:
Animals
Astrocytes - metabolism
Biological and medical sciences
Cell Count
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disease Models, Animal
Male
Medical sciences
Mice
Mice, Inbred BALB C
Microglia - metabolism
mouse model
MPTP
near infrared light
Nervous system (semeiology, syndromes)
Nervous system as a whole
Neurology
neuroprotection
Neuroprotective Agents
Parkinsonian Disorders - metabolism
Parkinsonian Disorders - therapy
Parkinson’s disease
Pars Compacta - metabolism
Phototherapy
Tyrosine 3-Monooxygenase - metabolism
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Summary:Highlights • Near infrared light (NIr), directed transcranially, is neuroprotective in rodent models of neurodegeneration. • We assessed the neuroprotective efficacy of remotely-applied NIr in an MPTP mouse model of parkinsonism. • As with transcranial NIr, remote NIr protects dopaminergic cells from damage due to mild MPTP doses. • The findings have important implications for the clinical translation of light-based therapies.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.05.023