Increased expression of Aquaporin 4 in the rat hippocampus and cortex during trimethyltin-induced neurodegeneration

Highlights • AQP4 over-expression in perivascular astrocytes of the rat hippocampus and cortex. • IgG leakage in the hippocampal and cortical paravasal parenchyma of TMT-treated rats. • Enhanced neuronal VEGF/VEGFR-2 production and VEGFR-2 activation (VEGFR-2P).

Saved in:
Bibliographic Details
Published in:Neuroscience 2014-08, Vol.274, p.273-288
Main Authors: Ceccariglia, S, D’altocolle, A, Del Fa’, A, Silvestrini, A, Barba, M, Pizzolante, F, Repele, A, Michetti, F, Gangitano, C
Format: Article
Language:English
Subjects:
Animals
Antigens, Nuclear - metabolism
Aquaporin 4
Aquaporin 4 - metabolism
Astrocytes - metabolism
Biological and medical sciences
Cerebral Cortex - metabolism
cortex
Disease Models, Animal
Female
Fundamental and applied biological sciences. Psychology
Glial Fibrillary Acidic Protein - metabolism
hippocampus
Hippocampus - metabolism
Immunoglobulin G - metabolism
Nerve Tissue Proteins - metabolism
neurodegeneration
Neurodegenerative Diseases - metabolism
Neurology
Neurons - metabolism
Phosphorylation
Rats, Wistar
RNA, Messenger - metabolism
trimethyltin
Trimethyltin Compounds
Vascular Endothelial Growth Factor A - metabolism
Vascular Endothelial Growth Factor Receptor-2 - metabolism
vascular endothelium growth factor
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • AQP4 over-expression in perivascular astrocytes of the rat hippocampus and cortex. • IgG leakage in the hippocampal and cortical paravasal parenchyma of TMT-treated rats. • Enhanced neuronal VEGF/VEGFR-2 production and VEGFR-2 activation (VEGFR-2P).
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.05.047