Hippocampal damage and affective disorders after treatment of cerebral aneurysms

Despite good neurological outcome after the treatment of ruptured or incidental cerebral aneurysms, many patients complain about mood disturbances such as anxiety and depression. The present study investigated the nature of these affective disorders, their trigger factors, and corresponding structur...

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Bibliographic Details
Published in:Journal of neurology 2014-11, Vol.261 (11), p.2128-2135
Main Authors: Wostrack, Maria, Friedrich, Benjamin, Hammer, Katrin, Harmening, Kathrin, Stankewitz, Anne, Ringel, Florian, Shiban, Ehab, Boeckh-Behrens, Tobias, Prothmann, Sascha, Zimmer, Claus, Meyer, Bernhard, Förschler, Annette, Ryang, Yu-Mi
Format: Article
Language:English
Subjects:
Adult
Aged
Aneurysms
Anxiety
Cognitive ability
Disease
Emotional disorders
Endovascular Procedures - adverse effects
Endovascular Procedures - trends
Female
Hemorrhage
Hippocampus - pathology
Hospitals
Humans
Intracranial Aneurysm - diagnosis
Intracranial Aneurysm - surgery
Intracranial Aneurysm - therapy
Male
Medicine
Medicine & Public Health
Middle Aged
Mood disorders
Mood Disorders - diagnosis
Mood Disorders - etiology
Neurology
Neuropsychology
Neuroradiology
Neurosciences
Original Communication
Postoperative Complications - diagnosis
Postoperative Complications - etiology
Spectrum analysis
Stroke
Surgery
Treatment Outcome
Young Adult
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Description
Summary:Despite good neurological outcome after the treatment of ruptured or incidental cerebral aneurysms, many patients complain about mood disturbances such as anxiety and depression. The present study investigated the nature of these affective disorders, their trigger factors, and corresponding structural brain changes. We assessed 63 patients matched by history of previous subarachnoid hemorrhage (SAH) and treatment modality (clipping vs. coiling) by a test battery including the Hospital Anxiety and Depression Scale (HADS) and beck depression inventory-II (BDI-II). MR imaging for the evaluation of structural changes included H 1 -MR spectroscopy, hippocampal volumetry, and diffusion tensor imaging (DTI). The applied multimodal imaging revealed no significant differences between patients with previous SAH and patients with incidental aneurysms; there were also no substantial differences between patients with and without previous SAH with respect to depression and anxiety. However, we observed significantly higher mean HADS scores in patients treated surgically versus patients treated by coiling ( p  
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-014-7464-y