Sensing the neuronal glycocalyx by glial sialic acid binding immunoglobulin-like lectins

Highlights • Siglecs bind to sialic acids of the intact glycocalyx. • Inhibitory Siglec-signaling keeps glial cells in a homeostatic status. • Microglial Siglecs are involved in modulation of neuron–microglia interaction. • Siglecs can be neuroprotective by preventing primary phagocytosis and the as...

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Bibliographic Details
Published in:Neuroscience 2014-09, Vol.275, p.113-124
Main Authors: Linnartz-Gerlach, B, Mathews, M, Neumann, H
Format: Article
Language:English
Subjects:
Animals
Glycocalyx - metabolism
Humans
Microglia - metabolism
Neuroglia - metabolism
Neurology
Neurons - metabolism
Phagocytosis - physiology
Sialic Acid Binding Immunoglobulin-like Lectins - metabolism
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Summary:Highlights • Siglecs bind to sialic acids of the intact glycocalyx. • Inhibitory Siglec-signaling keeps glial cells in a homeostatic status. • Microglial Siglecs are involved in modulation of neuron–microglia interaction. • Siglecs can be neuroprotective by preventing primary phagocytosis and the associated oxidative burst. • Siglec-3/CD33 variants are linked to Alzheimer’s disease.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.05.061