Sensing the neuronal glycocalyx by glial sialic acid binding immunoglobulin-like lectins

Highlights • Siglecs bind to sialic acids of the intact glycocalyx. • Inhibitory Siglec-signaling keeps glial cells in a homeostatic status. • Microglial Siglecs are involved in modulation of neuron–microglia interaction. • Siglecs can be neuroprotective by preventing primary phagocytosis and the as...

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Published in:Neuroscience 2014-09, Vol.275, p.113-124
Main Authors: Linnartz-Gerlach, B, Mathews, M, Neumann, H
Format: Article
Language:English
Subjects:
Animals
Glycocalyx - metabolism
Humans
Microglia - metabolism
Neuroglia - metabolism
Neurology
Neurons - metabolism
Phagocytosis - physiology
Sialic Acid Binding Immunoglobulin-like Lectins - metabolism
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container_title Neuroscience
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creator Linnartz-Gerlach, B
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Neumann, H
description Highlights • Siglecs bind to sialic acids of the intact glycocalyx. • Inhibitory Siglec-signaling keeps glial cells in a homeostatic status. • Microglial Siglecs are involved in modulation of neuron–microglia interaction. • Siglecs can be neuroprotective by preventing primary phagocytosis and the associated oxidative burst. • Siglec-3/CD33 variants are linked to Alzheimer’s disease.
doi_str_mv 10.1016/j.neuroscience.2014.05.061
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subjects Animals
Glycocalyx - metabolism
Humans
Microglia - metabolism
Neuroglia - metabolism
Neurology
Neurons - metabolism
Phagocytosis - physiology
Sialic Acid Binding Immunoglobulin-like Lectins - metabolism
title Sensing the neuronal glycocalyx by glial sialic acid binding immunoglobulin-like lectins
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