Peripheral and intra-dorsolateral striatum injections of the cannabinoid receptor agonist WIN 55,212-2 impair consolidation of stimulus–response memory

Highlights • Effect of cannabinoids on dorsolateral striatum-dependent habit memory is examined. • Rats are trained in two water maze tasks that depend on the dorsolateral striatum. • Post-training peripheral or intra-striatal cannabinoid agonist impairs memory consolidation. • These findings may be...

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Bibliographic Details
Published in:Neuroscience 2014-08, Vol.274, p.128-137
Main Authors: Goodman, J, Packard, M.G
Format: Article
Language:English
Subjects:
Animals
Benzoxazines - administration & dosage
Biological and medical sciences
cannabinoid
Cannabinoid Receptor Agonists - administration & dosage
caudate-putamen
dorsolateral striatum
Fundamental and applied biological sciences. Psychology
habit memory
Male
marijuana
Maze Learning - drug effects
Maze Learning - physiology
Medical sciences
Morpholines - administration & dosage
Motor Activity - drug effects
Naphthalenes - administration & dosage
Neostriatum - drug effects
Neostriatum - physiology
Neurology
Neuropharmacology
Pharmacology. Drug treatments
post-traumatic stress disorder
Psychodysleptics: hallucinogen
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Long-Evans
Spatial Memory - drug effects
Spatial Memory - physiology
Vertebrates: nervous system and sense organs
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Summary:Highlights • Effect of cannabinoids on dorsolateral striatum-dependent habit memory is examined. • Rats are trained in two water maze tasks that depend on the dorsolateral striatum. • Post-training peripheral or intra-striatal cannabinoid agonist impairs memory consolidation. • These findings may be relevant to treating human psychopathologies characterized by habitual behaviors.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.05.007