Inhibition of receptor activator of nuclear factor-κB ligand- or lipopolysaccharide-induced osteoclast formation by conophylline through downregulation of CREB

Highlights • The inhibitory effect of conophylline (CNP) on osteoclast formation by RANKL. • The Inhibitory effect of CNP on osteoclast formation by LPS. • The suppressive effect of CNP is on CREB activation by RANKL or LPS.

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Bibliographic Details
Published in:Immunology letters 2014-09, Vol.161 (1), p.31-37
Main Authors: Koide, Naoki, Kondo, Yuichiro, Odkhuu, Erdenezaya, Ulziisaikhan, Jambalganiin, Ukaji, Tamami, Yokochi, Takashi, Umezawa, Kazuo
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
ARL6ip
Bone Marrow Cells - drug effects
Bone Marrow Cells - metabolism
Cell Line
Conophylline
CREB
Cyclic AMP Response Element-Binding Protein - genetics
Cyclic AMP Response Element-Binding Protein - metabolism
Down-Regulation
Gene Expression Regulation - drug effects
Lipopolysaccharide
Lipopolysaccharides - pharmacology
Mice
Mitogen-Activated Protein Kinases - metabolism
NF-kappa B - metabolism
NFATC Transcription Factors - genetics
Osteoclast
Osteoclasts - drug effects
Osteoclasts - metabolism
Proto-Oncogene Proteins c-fos - genetics
RANK Ligand - pharmacology
Receptor activator of nuclear factor-κB ligand
Signal Transduction - drug effects
Vinca Alkaloids - pharmacology
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Description
Summary:Highlights • The inhibitory effect of conophylline (CNP) on osteoclast formation by RANKL. • The Inhibitory effect of CNP on osteoclast formation by LPS. • The suppressive effect of CNP is on CREB activation by RANKL or LPS.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2014.04.006