Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: Possible role of l -arginine-NO-cGMP pathway and BDNF levels

Highlights • Chronic treatment with hesperidin exerts antidepressant-like effect in the TST. • Hesperidin caused a significant decrease in NOX levels in the hippocampus. • Antidepressant-like effect of hesperidin was modulated by l -arginine-NO-cGMP pathway. • Effect of hesperidin also is associated...

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Bibliographic Details
Published in:Brain research bulletin 2014-05, Vol.104, p.19-26
Main Authors: Donato, Franciele, de Gomes, Marcelo Gomes, Goes, André Tiago Rossito, Filho, Carlos Borges, Del Fabbro, Lucian, Antunes, Michelle S, Souza, Leandro Cattelan, Boeira, Silvana Peterini, Jesse, Cristiano Ricardo
Format: Article
Language:English
Subjects:
Animals
Antidepressive Agents - administration & dosage
Antidepressive Agents - pharmacology
Arginine - metabolism
Brain diseases
Brain-Derived Neurotrophic Factor - metabolism
Cyclic GMP - metabolism
Depression
Flavonoid
Hesperidin - administration & dosage
Hesperidin - pharmacology
Hippocampus - drug effects
Hippocampus - metabolism
Male
Mechanisms
Mice
Motor Activity - drug effects
Neurology
Neurotrophic factors
Nitric Oxide - metabolism
Signal Transduction - drug effects
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Summary:Highlights • Chronic treatment with hesperidin exerts antidepressant-like effect in the TST. • Hesperidin caused a significant decrease in NOX levels in the hippocampus. • Antidepressant-like effect of hesperidin was modulated by l -arginine-NO-cGMP pathway. • Effect of hesperidin also is associated with an increase in hippocampal BDNF levels.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2014.03.004