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Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: Possible role of l -arginine-NO-cGMP pathway and BDNF levels
Highlights • Chronic treatment with hesperidin exerts antidepressant-like effect in the TST. • Hesperidin caused a significant decrease in NOX levels in the hippocampus. • Antidepressant-like effect of hesperidin was modulated by l -arginine-NO-cGMP pathway. • Effect of hesperidin also is associated...
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| Published in: | Brain research bulletin 2014-05, Vol.104, p.19-26 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c468t-e67d736a19a750c9138253b71534e726a753839526336aa27a09368e2e3426673 |
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| cites | cdi_FETCH-LOGICAL-c468t-e67d736a19a750c9138253b71534e726a753839526336aa27a09368e2e3426673 |
| container_end_page | 26 |
| container_issue | |
| container_start_page | 19 |
| container_title | Brain research bulletin |
| container_volume | 104 |
| creator | Donato, Franciele de Gomes, Marcelo Gomes Goes, André Tiago Rossito Filho, Carlos Borges Del Fabbro, Lucian Antunes, Michelle S Souza, Leandro Cattelan Boeira, Silvana Peterini Jesse, Cristiano Ricardo |
| description | Highlights • Chronic treatment with hesperidin exerts antidepressant-like effect in the TST. • Hesperidin caused a significant decrease in NOX levels in the hippocampus. • Antidepressant-like effect of hesperidin was modulated by l -arginine-NO-cGMP pathway. • Effect of hesperidin also is associated with an increase in hippocampal BDNF levels. |
| doi_str_mv | 10.1016/j.brainresbull.2014.03.004 |
| format | article |
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de Gomes, Marcelo Gomes ; Goes, André Tiago Rossito ; Filho, Carlos Borges ; Del Fabbro, Lucian ; Antunes, Michelle S ; Souza, Leandro Cattelan ; Boeira, Silvana Peterini ; Jesse, Cristiano Ricardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-e67d736a19a750c9138253b71534e726a753839526336aa27a09368e2e3426673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Antidepressive Agents - administration & dosage</topic><topic>Antidepressive Agents - pharmacology</topic><topic>Arginine - metabolism</topic><topic>Brain diseases</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>Cyclic GMP - metabolism</topic><topic>Depression</topic><topic>Flavonoid</topic><topic>Hesperidin - administration & dosage</topic><topic>Hesperidin - pharmacology</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Male</topic><topic>Mechanisms</topic><topic>Mice</topic><topic>Motor Activity - drug effects</topic><topic>Neurology</topic><topic>Neurotrophic factors</topic><topic>Nitric Oxide - metabolism</topic><topic>Signal Transduction - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Donato, Franciele</creatorcontrib><creatorcontrib>de Gomes, Marcelo Gomes</creatorcontrib><creatorcontrib>Goes, André Tiago Rossito</creatorcontrib><creatorcontrib>Filho, Carlos Borges</creatorcontrib><creatorcontrib>Del Fabbro, Lucian</creatorcontrib><creatorcontrib>Antunes, Michelle S</creatorcontrib><creatorcontrib>Souza, Leandro Cattelan</creatorcontrib><creatorcontrib>Boeira, Silvana Peterini</creatorcontrib><creatorcontrib>Jesse, Cristiano Ricardo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Donato, Franciele</au><au>de Gomes, Marcelo Gomes</au><au>Goes, André Tiago Rossito</au><au>Filho, Carlos Borges</au><au>Del Fabbro, Lucian</au><au>Antunes, Michelle S</au><au>Souza, Leandro Cattelan</au><au>Boeira, Silvana Peterini</au><au>Jesse, Cristiano Ricardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: Possible role of l -arginine-NO-cGMP pathway and BDNF levels</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>104</volume><spage>19</spage><epage>26</epage><pages>19-26</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><abstract>Highlights • Chronic treatment with hesperidin exerts antidepressant-like effect in the TST. • Hesperidin caused a significant decrease in NOX levels in the hippocampus. • Antidepressant-like effect of hesperidin was modulated by l -arginine-NO-cGMP pathway. • Effect of hesperidin also is associated with an increase in hippocampal BDNF levels.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24709058</pmid><doi>10.1016/j.brainresbull.2014.03.004</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0361-9230 |
| ispartof | Brain research bulletin, 2014-05, Vol.104, p.19-26 |
| issn | 0361-9230 1873-2747 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Animals Antidepressive Agents - administration & dosage Antidepressive Agents - pharmacology Arginine - metabolism Brain diseases Brain-Derived Neurotrophic Factor - metabolism Cyclic GMP - metabolism Depression Flavonoid Hesperidin - administration & dosage Hesperidin - pharmacology Hippocampus - drug effects Hippocampus - metabolism Male Mechanisms Mice Motor Activity - drug effects Neurology Neurotrophic factors Nitric Oxide - metabolism Signal Transduction - drug effects |
| title | Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: Possible role of l -arginine-NO-cGMP pathway and BDNF levels |
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