Selenium partially prevents cisplatin-induced neurotoxicity: A preliminary study

• Published in: Neurotoxicology (Park Forest South) 2014-05, Vol.42, p.71-75
• Main Authors: Erken, Haydar Ali, Koç, Emine Rabia, Yazıcı, Haşmet, Yay, Arzu, Önder, Gözde Özge, Sarıcı, Saim Furkan
• Format: Article
• Language: English
• Subjects: Action Potentials - drug effects; Action Potentials - physiology; Animals; Antineoplastic agents; Antineoplastic Agents - adverse effects; Axons - drug effects; Biological and medical sciences; Chemotherapy; Cisplatin; Cisplatin - antagonists & inhibitors; Cisplatin - toxicity; Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction; Male; Medical sciences; Nerve Degeneration; Nervous system (semeiology, syndromes); Neural Conduction - drug effects; Neural Conduction - physiology; Neurology; Neuropathy; Neuroprotective Agents - pharmacology; Neuroprotective effect; Neurotoxicity; Pharmacology. Drug treatments; Pilot Projects; Prevention and actions; Public health. Hygiene; Public health. Hygiene-occupational medicine; Rats; Sciatic Nerve - cytology; Sciatic Nerve - drug effects; Sciatic Nerve - physiology; Selenium; Selenium - pharmacology; Toxicology; Trace Elements - pharmacology
• ISSN: 0161-813X; 1872-9711
• DOI: 10.1016/j.neuro.2014.04.002

•Cisplatin is a neurotoxic drug but selenium has a neuroprotective effect.•We investigate that whether selenium prevent cisplatin-induced neurotoxicity.•Selenium partially prevents cisplatin induced-neurotoxicity. Cisplatin is an anticancer drug and it has neurotoxic effects. On the other hand, the neuroprotective effect of selenium was observed in previous studies. However, the effect of selenium on cisplatin-induced neurotoxicity has not been studied yet. Therefore, we aimed to investigate whether selenium prevent cisplatin-induced neurotoxicity. Twenty-one male Wistar albino rats were divided into three groups: control (C), cisplatin (CS), cisplatin and selenium (CSE, n=7 in each group). Cisplatin (12mg/kg/day, i.p.) was administered for 3 days to CS and CSE groups. Also, CSE group received via oral gavage 3mg/kg/day (twice-a-day as 1.5mg/kg) selenium 5 days before of cisplatin injection and continued for 11 consecutive days. The same volumes of saline were intraperitoneally and orally administered to C group at same time. At the end of experimental protocol, electrophysiological and histopathological examinations were performed. The nerve conduction velocity, amplitude of compound action potential and number of axon of CS group were significantly lower than the C group. However, the same parameters of CSE group were significantly higher than the CS group. Although, cisplatin has a peripheral neurotoxic effect in rats, this effect was partially prevented by selenium treatment. Thus, it appears that co-administration of selenium and cisplatin may be a useful approach to decrease severity of peripheral neurotoxicity.