Th17 cell plays a role in the pathogenesis of Hashimoto's thyroiditis in patients

Abstract Hashimoto's thyroiditis (HT) has long been epidemiologically associated with excess iodine levels. However, the underlying immunological mechanisms still remain largely unexplored. Th17 cells are commonly recognized as playing vital roles in various autoimmune diseases. Here we show th...

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Bibliographic Details
Published in:Clinical immunology (Orlando, Fla.) Fla.), 2013-12, Vol.149 (3), p.411-420
Main Authors: Li, Dapeng, Cai, Wenqian, Gu, Runxia, Zhang, Yi, Zhang, Huafeng, Tang, Ke, Xu, Pingwei, Katirai, Foad, Shi, Wei, Wang, Longqiang, Huang, Tao, Huang, Bo
Format: Article
Language:English
Subjects:
Adult
Aged
Allergy and Immunology
Animals
Autoimmune thyroiditis
Case-Control Studies
Cell Differentiation - drug effects
Cell Movement - drug effects
Female
Fibrosis
Hashimoto Disease - blood
Hashimoto Disease - immunology
Hashimoto Disease - pathology
Hashimoto's thyroiditis
Humans
IL-17
Interleukin-17 - biosynthesis
Interleukin-17 - blood
Interleukin-17 - immunology
Iodine
Iodine - pharmacology
Male
Mice
Middle Aged
Organ Specificity
Regulatory T cell
Spleen - immunology
Spleen - metabolism
Spleen - pathology
Th1 Cells - immunology
Th1 Cells - metabolism
Th1 Cells - pathology
Th17 cell
Th17 Cells - immunology
Th17 Cells - metabolism
Th17 Cells - pathology
Thyroid Gland - immunology
Thyroid Gland - metabolism
Thyroid Gland - pathology
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Summary:Abstract Hashimoto's thyroiditis (HT) has long been epidemiologically associated with excess iodine levels. However, the underlying immunological mechanisms still remain largely unexplored. Th17 cells are commonly recognized as playing vital roles in various autoimmune diseases. Here we show that intra-thyroid infiltrating Th17 cells and serum IL-17 levels were significantly increased in HT patients. However, the concentration of serum IL-17 was inversely correlated with patients' residual thyroid function while the heterogeneously expressed thyroid IL-17 was directly correlated with local fibrosis. Administration of moderate high levels of iodine was found to facilitate the polarization of murine splenic naïve T cells into Th17 cells, whereas extreme high levels of iodine favored Th1 polarization and inhibited Treg development. These findings suggest that both Th1 and Th17 cells may be involved in the pathogenesis of HT and high levels of iodine may play a critical role in this process by modulating T cell differentiation.
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2013.10.001